# US 5,702,729 A · Methods for the prevention and treatment of gastrointestinal disorders caused or mediated by algae or cyanobacteria

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 5,702,729 A
- Document ID: US5702729A
- Status: Granted
- Kind: A
- Application number: 08/569,028
- Filed: 1995-12-07
- Granted: 1997-12-30
- Earliest claimed: 1995-12-07
- Assignees: The Procter & Gamble Company
- Inventors: Jamesina Anne Fitzgerald
- Web page: https://patentgrep.com/patent/US5702729A

## CPC

- A61K 33/245: Bismuth; Compounds thereof
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The subject invention encompasses methods for the prevention and treatment of a human or lower animal subject having a gastrointestinal disorder caused or mediated by algae and/or cyanobacteria comprising administering bismuth to the subject.

## Claims

### Claim 1

A method for treatment of a human or lower animal subject having a gastrointestinal disorder caused or mediated by one or more organisms selected from the group consisting of algae, cyanobacteria, and combinations thereof, comprising administering to the subject from about 50 milligrams to about 5000 milligrams of bismuth, per day, for from about 1 to 56 days.

### Claim 2 (depends on 1)

The method of claim 1 wherein the bismuth is administered at a level of from about 50 milligrams to about 2500 milligrams, per day.

### Claim 3 (depends on 1)

The method of claim 1 wherein the bismuth is selected from the group consisting of bismuth aluminate, bismuth subcarbonate, bismuth subcitrate, bismuth citrate, tripotassium dicitrato bismuthate, bismuth subgalate, bismuth subsalicylate, bismuth tartrate, and mixtures thereof.

### Claim 4 (depends on 1)

The method of claim 1 wherein the organisms are cyanobacteria selected from the group consisting of Microcystis aeruginosa, Aphanizomenon flos-aquae, and Anabaena flos-aqua, and combinations thereof.

### Claim 5

A method for prevention in a human or lower animal subject in need thereof, of a gastrointestinal disorder caused or mediated by one or more one or more organisms selected from the group consisting of algae, cyanobacteria, and combinations thereof, comprising administering to the subject from about 50 milligrams to about 5000 milligrams of bismuth, per day, for from about 1 to 21 days.

### Claim 6 (depends on 5)

The method of claim 5 wherein the bismuth is administered at a level of from about 50 milligrams to about 2500 milligrams, per day.

### Claim 7 (depends on 5)

The method of claim 5 wherein the bismuth is selected from the group consisting of bismuth aluminate, bismuth subcarbonate, bismuth subcitrate, bismuth citrate, tripotassium dicitrato bismuthate, bismuth subgalate, bismuth subsalicylate, bismuth tartrate, and mixtures thereof.

### Claim 8 (depends on 5)

The method of claim 5 wherein the organisms are algae and cyanobacteria selected from the group consisting of Chlorella, Chlorococcum, Microcystis aeruginosa, Anabaena flos-aqua, Aphanizomenon flos-aquae, and combinations thereof.