# US 5,702,711 A · Method for enhancing the rate of skin permeation of lactic acid through use of the L-enantiomer

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- Number: US 5,702,711 A
- Document ID: US5702711A
- Status: Granted
- Kind: A
- Application number: 08/452,483
- Filed: 1995-05-26
- Granted: 1997-12-30
- Earliest claimed: 1994-03-22
- Assignees: Bristol-Myers Squibb Company
- Inventors: Prakash Parab
- Web page: https://patentgrep.com/patent/US5702711A

## CPC

- A61K 31/205: Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- A61P 17/00: Drugs for dermatological disorders
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Methods of increasing the rate of lactic acid permeation in skin for the treatment of dermatological disorders by applying a composition containing an inorganic or organic salt of lactic acid in a dermatologically acceptable composition wherein at least 70% of the lactic acid moiety in the salt is L-lactic acid, and compositions for practicing such methods.

## Claims

### Claim 1

A method of increasing the rate of L-lactic acid permeation in mammalian skin comprising applying to said skin a composition containing a therapeutic amount of a mixture of an inorganic or organic lactate salt in a dermatologically acceptable carrier, 100% by weight of the lactate salt being an L-lactate salt.

### Claim 2

A method of increasing the rate of L-lactic acid permeation in mammalian skin, comprising applying to said skin a composition containing a therapeutic amount of a mixture of an inorganic or organic lactate salt in a dermatologically acceptable carrier, from about 70% to about 100% by weight of the lactate salt being an L-lactate salt.

### Claim 3 (depends on 2)

The method as claimed in claim 2 wherein the salt of lactic acid is an organic salt.

### Claim 4 (depends on 3)

The method as claimed in claim 3 wherein the salt is a salt of an amino acid.

### Claim 5 (depends on 4)

The method as claimed in claim 4 wherein the amino acid is selected from the group consisting of lysine and histidine.

### Claim 6 (depends on 1, 2, 3, 4, 5)

The method as claimed in claims 1, 2, 3, 4 or 5 wherein the composition has a pH of from 2.5 to 9.

### Claim 7 (depends on 1, 2, 3, 4, 5)

The method as claimed in claim 1, 2, 3, 4 or 5 wherein at least about 85% of the lactic acid moiety is L-lactic acid.

### Claim 8 (depends on 1, 2, 3, 4, 5)

The method as claimed in claim 1, 2, 3, 4 or 5 wherein the composition has a pH of from about 3.5 to 7 and at least about 85% of the lactic acid moiety of is L-lactic acid.

### Claim 9 (depends on 2)

The method as claimed in claim 2 wherein salt of lactic acid is an inorganic salt.

### Claim 10 (depends on 9)

The method as claimed in claim 9 wherein the salt is selected from the group consisting of ammonium, sodium and potassium salts.

### Claim 11 (depends on 9, 10)

The method as claimed in claim 9 or 10 wherein the composition has a pH of from 2.5 to 9.

### Claim 12 (depends on 9, 10)

The method as claimed in claim 9 or 10 wherein at least about 85% of the lactic acid moiety is L-lactic acid.

### Claim 13 (depends on 9, 10)

The method as claimed in claim 9 or 10 wherein the composition has a pH of from about 3.5 to 7 and at least about 85% of the lactic acid moiety is L-lactic acid.