# US 5,702,703 A · Bacillus thuringiensis toxin enhancer

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- Number: US 5,702,703 A
- Document ID: US5702703A
- Status: Granted
- Kind: A
- Application number: 08/340,563
- Filed: 1994-11-16
- Granted: 1997-12-30
- Earliest claimed: 1994-11-16
- Assignees: Mycogen Corporation
- Inventors: H. Ernest Schnepf; Brian Stockhoff; Mark Knuth
- Web page: https://patentgrep.com/patent/US5702703A

## CPC

- A01N 47/28: Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< (isoureas, isothioureas A01N47/42)
- A01N 63/23: B. thuringiensis
- A01N 63/50: Isolated enzymes; Isolated proteins (peptides A01N37/46)
- Y10S 435/832: Bacillus
- Y10S 435/834: Bacillus cereus
- Y10S 530/825: Bacteria
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

The activity of pesticides is enhanced by application of a zwittermicin antibiotic in combination with insecticides. In particular, zwittermicin enhances the activity of Bacillus thuringiensis .delta.-endotoxins.

## Claims

### Claim 1

A method of enhancing the activity of a pesticide which comprises applying the pesticide in combination with zwittermicin A, zwittermicin Ac, or mixtures thereof in pesticidal-enhancing amounts.

### Claim 2 (depends on 1)

The method, according to claim 1, wherein the pesticide is applied in combination with zwittermicin A.

### Claim 3 (depends on 1)

The method, according to claim 1, wherein the pesticide is a biological insecticide.

### Claim 4 (depends on 3)

The method, according to claim 3, wherein the biological insecticide is selected from the group consisting of a Bacillus thuringiensis .delta.-endotoxin, rotenone, a pyrethrin, avermectin, azadirachtin, and mixtures thereof.

### Claim 5 (depends on 4)

The method, according to claim 4, wherein the biological insecticide is a Bacillus thuringiensis .delta.-endotoxin.

### Claim 6 (depends on 5)

The method, according to claim 5, wherein the Bacillus thuringiensis .delta.-endotoxin is selected from the group consisting of CryI, CryII, CryIII, CryIV, CryV, and CryVI, and fragments thereof which retain insecticidal activity.

### Claim 7

A pesticidal composition which comprises components (a), (b), and (c); wherein component (a) is a pesticide; component (b) is selected from the group consisting of a pesticidal-enhancing amount of zwittermicin A, zwittermicin Ac, or mixtures thereof; and component (c) is an agriculturally acceptable formulation.

### Claim 8 (depends on 7)

The composition, according to claim 7, wherein the pesticide is a biological insecticide.

### Claim 9 (depends on 8)

The composition, according to claim 8, wherein the biological insecticide is a Bacillus thuringiensis .delta.-endotoxin.

### Claim 10 (depends on 9)

The composition, according to claim 9, wherein the Bacillus thuringiensis .delta.-endotoxin is selected from the group consisting of CryI, CryII, CryIII, CryIV, CryV, and CryVI, and fragments thereof which retain insecticidal activity.

### Claim 11 (depends on 10)

The composition, according to claim 10, wherein component (b) is zwittermicin A.