# US 5,702,695 A · Osseointegration promoting implant composition, implant assembly and method therefor > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 5,702,695 A - Document ID: US5702695A - Status: Granted - Kind: A - Application number: 08/481,501 - Filed: 1995-06-16 - Granted: 1997-12-30 - Earliest claimed: 1995-06-16 - Assignees: McGill University - Inventors: Cameron Malcolm Lang Clokie - Web page: https://patentgrep.com/patent/US5702695A ## CPC - A61K 38/1841: {Transforming growth factor [TGF]} - A61C 8/0018: {characterised by the shape} - A61C 8/005: {Connecting devices for joining an upper structure with an implant member, e.g. spacers} - A61C 8/0054: {having a cylindrical implant connecting part} - A61C 8/0069: {tapered or conical connection} - A61L 27/227: {Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24} - A61P 19/00: Drugs for skeletal disorders - A61C 8/006: {with polygonal positional means, e.g. hexagonal or octagonal} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61C: DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE (non-driven toothbrushes A46B; {tongue scrapers A61B17/24;} preparations for dentistry A61K6/00; preparations for cleaning the teeth or mouth A61K8/00, A61Q11/00) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract A liquid composition comprising a transforming growth factor .beta.(TGF-/.beta. in a polyoxyalkylene block copolymer--containing liquid carrier which gels at about 37 C, promotes osseointegration of an implant in bone, when introduced into a bore in the bone, prior to the insertion of the implant in the bone. ## Claims ### Claim 1 An osseointegration promoting implant composition having a liquid form adapted to be injected in a bore in a bone prior to insertion of an implant in the bore, said liquid form readily flowing along an interspace between said bore and said implant of 10 to 100 microns width, said composition consisting essentially of a transforming growth factor .beta. (TGF-.beta.) in a liquid carrier, said liquid carrier being gelable at about 37.degree. C., said TGF-.beta. being present in said liquid carrier in an amount effective to promote osseointegration at the interface between the bore and the bone for the implant, and an outer surface of the implant; said composition having a liquid state at a temperature other than normal body temperature, said liquid carrier being effective in gel form at about 37.degree. C. to prevent settling of the TGF-.beta. in the composition and provide slow and sustained release of the TGF-.beta., at the interface between the bore in the bone for the implant, and the outer surface of the implant, said liquid carrier consisting essentially of an inversely soluble polyoxyalkylene block copolymer having a molecular weight of at least 1000 and bearing terminal hydroxyl groups, in an aqueous medium. ### Claim 2 (depends on 1) A composition according to claim 1, wherein said TGF-.beta. is TGF-.beta..sub.1. ### Claim 3 (depends on 1) A composition according to claim 1, wherein said polyoxyalkylene block copolymer has a molecular weight of 1000 to 16,000, said composition reversibly interchanging between gel and liquid states, dependent on temperature. ### Claim 4 (depends on 2) A composition according to claim 2, wherein said TGF-.beta..sub.1 is present in a concentration of 5 to 15 .mu.g/ml. ### Claim 5 (depends on 1) A composition according to claim 1, wherein said liquid carrier is a liquid at a temperature below 10.degree. C. and said polyoxyalkylene block copolymer has a molecular weight of about 12,500, and is in said aqueous medium, in a concentration of about 15 to 30%, by weight, said block copolymer being composed of about 70% ethylene oxide and 30% propylene oxide, by weight, said composition reversibly interchanging between gel and liquid states, dependent on temperature. ### Claim 6 A composition consisting essentially of a transforming growth factor .beta. (TGF-.beta.) in a liquid carrier having a liquid form adapted to be injected in a bore of a bone prior to placing an implant in the bore, said liquid form being a readily flowable, pourable liquid having a viscosity comparable with that of water such that it can be readily injected and will flow along an interspace between the bore and the implant of 10 to 100 microns width, said gel being essentially non-pourable having a viscosity comparable with that of petroleum jelly, said liquid composition being gelable at about 37.degree. C., and said TGF-.beta. being present in said liquid composition in a concentration effective in the interspace between an inner surface of said bore and an outer surface of said implant, to promote osseointegration at the interface between said inner surface and said outer surface; said composition having a liquid state at a temperature other than normal body temperature, said liquid carrier consisting essentially of an inversely soluble polyoxyalkylene block copolymer having a molecular weight of at least 1000 and bearing terminal hydroxyl groups, in an aqueous medium. ### Claim 7 (depends on 6) A composition according to claim 6, wherein said liquid carrier is a liquid at a temperature below 10.degree. C. and said polyoxyalkylene block copolymer has a molecular weight of about 12,500, and is in said aqueous medium, in a concentration of about 15 to 30%, by weight, said block copolymer being composed of about 70% ethylene oxide and 30% propylene oxide, by weight, said composition reversibly interchanging between gel and liquid states, dependent on temperature. ### Claim 8 (depends on 6) A composition according to claim 6, wherein said TGF-.beta. is TGF-.beta.-1 present in a concentration of 5 to 15 .mu.g/ml. ### Claim 9 (depends on 7) A composition according to claim 7, wherein said TGF-.beta. is TGF-.beta.-1 present in a concentration of 5 to 15 .mu.g/ml. ### Claim 10 (depends on 1) A composition according to claim 1, wherein said polyoxyalkylene block copolymer is represented by HO(CH.sub.2 CH.sub.2 O).sub.a --(CH(CH.sub.3)CH.sub.2 OH).sub.b (CH.sub.2 CH.sub.2 O).sub.c H where segment b comprises at least 15%, by weight, and segments a+c comprise 20 to 85%, by weight. ### Claim 11 (depends on 6) A composition according to claim 6, wherein said polyoxyalkylene block copolymer is represented by HO(CH.sub.2 CH.sub.2 O).sub.a --(CH(CH.sub.3)CH.sub.2 OH).sub.b (CH.sub.2 CH.sub.2 O).sub.c H where segment b comprises at least 15%, by weight, and segments a+c comprise 20 to 85%, by weight.