# US 5,702,694 A · Compositions for treating corns, calluses and warts

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- Number: US 5,702,694 A
- Document ID: US5702694A
- Status: Granted
- Kind: A
- Application number: 08/596,219
- Filed: 1996-02-12
- Granted: 1997-12-30
- Earliest claimed: 1993-08-17
- Assignees: Schering-Plough Healthcare Products, Inc.
- Inventors: Thomas W. Chamness
- Web page: https://patentgrep.com/patent/US5702694A

## CPC

- A61K 8/731: {Cellulose; Quaternized cellulose derivatives}
- A61K 8/347: {Phenols}
- A61K 31/05: Phenols {(cannabinoids A61K31/658)}
- A61Q 3/00: Manicure or pedicure preparations
- A61Q 19/00: Preparations for care of the skin
- A61K 2800/28: Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Topical compositions for the treatment of corns, calluses and warts comprising a benzenediol or a substituted 1,2-benzenediol and a pharmaceutically acceptable carrier, are described.

## Claims

### Claim 1

A topical composition comprising a about 2 to about 64% of a compound selected from the group consisting of hydroquinone; olivetol, pyrocatechol and nordihydroguaiaretic acid and a pharmaceutically acceptable carrier material wherein said carrier material is flexible collodion.

### Claim 2 (depends on 1)

A composition in accordance with claim 1 which further comprises an enhancer selected from the group consisting of salicylic acid, erucic acid, and propionic acid.

### Claim 3 (depends on 1)

A method for the treatment of hyperkeratinizing and hyperproliferative skin diseases and conditions which comprises topically administering a therapeutically effective amount of a composition defined in claim 1.

### Claim 4 (depends on 1)

A method for removing corns, calluses and warts which comprises topically administering a therapeutically effective amount of a composition defined in claim 1.

### Claim 5 (depends on 1)

A method in accordance with claim 1 wherein the compound is pyrocatechol.

### Claim 6 (depends on 1)

A method in accordance with claim 1 wherein the compound is nordihydroguaiaretic acid.

### Claim 7

A topical composition comprising on a weight/weight basis:
______________________________________ Percentage of Formula % (weight/weight) Component ______________________________________ 3-24 Pyrocatechol or Nordihydroguaiaretic acid 2-5 Balsam Fir (Oregon) 0.01-0.05 .beta.-Carotene, 22% in Vegetable Oil 5-15 Acetone 66-90 Flexible Collodion, USP ______________________________________

### Claim 8 (depends on 7)

A topical composition in accordance with claim 7 comprising:
______________________________________ Percentage of Formula % (weight/weight) Component ______________________________________ 6.0 Pyrocatechol 5.0 Balsam Fir (Oregon) 0.05 .beta.-Carotene 10.0 Acetone qs 100 Flexible Collodion, USP ______________________________________

### Claim 9 (depends on 7)

A topical composition in accordance with claim 7 comprising:
______________________________________ Percentage of Formula % (weight/weight) Component ______________________________________ 12.00 Pyrocatechol 10.00 Acetone 72.95 Flexible collodion (USP) 5.00 Balsam fir (Oregon) 0.05 .beta.-Carotene HSE 22% in vegetable oil ______________________________________

### Claim 10 (depends on 7)

A topical composition in accordance with claim 7 comprising:
______________________________________ Percentage of Formula % (weight/weight) Component ______________________________________ 12.00 Nordihydroguairaretic acid 10.00 Acetone 72.95 Flexible collodion (USP) 5.00 Balsam fir (Oregon) 0.05 .beta.-Carotene HSE 22% in vegetable oil ______________________________________

### Claim 11

A topical composition comprising on a weight/weight basis:
______________________________________ Percentage of Formula % (weight/weight) Component ______________________________________ 6-20 Nordihydroguaiaretic acid 30-60 Ethyl Alcohol (190 proof, USP) 15-50 Arlasolve 200 Liquid.sup.1 0.03-0.7 Klucel HXF-NF.sup.2 ______________________________________

### Claim 12 (depends on 11)

A topical composition in accordance with claim 11 comprising:
______________________________________ Percentage of Formula % (weight/weight) Component ______________________________________ 12.00 Nordihydroguaiaretic acid 48.50 Ethyl Alcohol (190 proof, USP) 39.00 Arlasolve 200 Liquid.sup.1 00.50 Klucel HXF-NF.sup.2 ______________________________________