Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
AssigneeNicox S.A.
InventorPiero Del Soldato
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Abstract
This invention is directed to nitric esters of derivatives of propionic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid, 5-benzoyl-1,2-dihydro-3H-pyrrolo1,2-a!pyrrole-1-carboxylic acid, 6-methoxy-2-napthylacetic acid, characterized in that they have the following general formula: ##STR1## These nitric ester derivatives may be formulated into pharmaceutical compositions and administered for their anti-inflammatory and/or analgesic activity.
Claims13
Derivatives of propionic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid, 5-benzoyl-1,2-dihidro-3H-pyrrolo1,2-a!pyrrole-1-charboxylic acid, 6-methoxy-2-napthylacetic acid, characterized in that they have the following general formula:
- ##STR31## where:
- A and B are chosen from hydrogen, linear or brached, substituted or non substituted alkyl chains, M is chosen from:
- ##STR32## where R is chosen from:
- ##STR33## Y is chosen among oxygen, NH, NR.sub.1, where R.sub.1 is a linear or branched alkyl group, and n is an integer from 1 and 10.
Dependencies are inferred from the claim text.