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US 5,700,920 AGranted
Carbocyclic nucleosides containing bicyclic rings, oligonucleotides therefrom, process for their preparation, their use and intermediates
AssigneeNovartis AG
InventorsKarl-Heinz Altmann, Rene Imwinkelried, Albert Eschenmoser
Life of this patent
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Abstract
Compounds of the formulae I and Ia and their racemates ##STR1## in which A is --CH.sub.2 -- or --CH.sub.2 CH.sub.2 --, R.sub.1 is hydrogen or a protective group, R.sub.2 is hydrogen or a protective group or a radical forming a phosphorus-containing nucleotide bridge group and B is a purine or pyrimidine radical or an analogue thereof, can be used as antiviral active ingredients or for the preparation of biologically active oligonucleotides.
Claims37
An oligonucleotide of the formula V
- 5'-U-(O-Y-O-V).sub.y O-Y-O-W-3' (V)
- in which U, V and W each are identical or different radicals of natural or synthetic nucleosides and at least one of the radicals U, V, and/or W is a radical of the formulae VI or VIa ##STR47## and y is a number from 0 to 200, Y is a nucleotide bridge group, B is a purine or pyrimidine radical or an analogue thereof, and A is --CH.sub.2 -- or --CH.sub.2 CH.sub.2 --.
Dependencies are inferred from the claim text.