Prosaposin and cytokine-derived peptides
AssigneeThe Regents of the University of California
InventorJohn S. O'Brien
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Abstract
Prosaposin and peptide derivatives derived therefrom will promote neurite outgrowth in vitro. A peptide consensus sequence was determined by comparing the active neurite outgrowth-inducing saposin C peptide sequence with that of various hematopoietic and neuropoietic cytokines. These cytokine-derived peptides will promote the same processes as their corresponding cytokines. In addition, prosaposin and saposin C promote increased nerve cell myelination ex vivo.
Claims9
A peptide consisting of the sequence YVKHQGLNKNINLDSVDGVP (SEQ ID NO:
- 2).
A peptide consisting of the sequence EALAENNLNLPKMAG (SEQ ID NO:
- 7).
A peptide consisting of the sequence LQMILNGINNYKNPKLT (SEQ ID NO:
- 8).
A peptide consisting of the sequence ILMENNLRRPNL (SEQ ID NO:
- 9).
A peptide consisting of the sequence FYLRNNQLVAGTL (SEQ ID NO:
- 10).
A peptide consisting of the sequence AEHCSLNENITVPDTKV (SEQ ID NO:
- 11).
A peptide consisting of the sequence YTAQGEPFPNNVEKLCAP (SEQ ID NO:
- 12).
A peptide consisting of the sequence FNKIEINNTKLEFESA (SEQ ID NO:
- 13).
A peptide consisting of the sequence RPNILGLRNNIYCMAQLL (SEQ ID NO:
- 14).
Dependencies are inferred from the claim text.