Capsular polysaccharide immunomodulator
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsArthur O. Tzianabos, Andrew B. Onderdonk, Dennis L. Kasper
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Abstract
Methods and products for protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. Methods for forming immunomodulators and pharmaceutical compositions relating thereto also are provided. The products useful in the invention are polysaccharides including a repeat unit having a positively charged free amino group and a negatively charged group. The preferred polysaccharide is B. fragilis capsular polysaccharide A.
Claims13
A method for inducing protection against abscess formation associated with infection comprising:
- administering to a subject in need of such protection a pharmaceutical preparation containing an effective amount for inducing protection against abscess formation of a polymer of repeating units of a charge motif characteristic of polysaccharide A, the motif being a positively charged free amino moiety and a negatively charged moiety selected from the group consisting of carboxyl, phosphate, phosphonate, sulfate and sulfonate, and wherein the polymer is free from complexation as part of a B. fragilis capsular polysaccharide complex.
Dependencies are inferred from the claim text.