# US 5,700,468 A · Extracts of ginkgo biloba and their methods of preparation

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- Number: US 5,700,468 A
- Document ID: US5700468A
- Status: Granted
- Kind: A
- Application number: 08/615,536
- Filed: 1996-03-12
- Granted: 1997-12-23
- Earliest claimed: 1988-09-20
- Assignees: Indena S.p.A.
- Inventors: Ezio Bombardelli; Giuseppe Mustich; Marco Bertani
- Web page: https://patentgrep.com/patent/US5700468A

## CPC

- A61K 36/16: Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
- A61K 31/70: Carbohydrates; Sugars; Derivatives thereof (sorbitol A61K31/047)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A process is provided for producing a purified extract from Ginkgo biloba leaves by solvent extraction with selected solvents. In the process, a crude or partially purified extract is subjected to solvent extraction with a solvent comprising toluene and n-butanol. Pharmaceutical compositions comprising dimeric flavones and/or polyphenols are also described.

## Claims

### Claim 1

A composition comprising compounds extracted from leaves of Ginkgo biloba and wherein inactive lipophilic substances which can be extracted by n-hexane, n-heptane or a solvent comprising toluene and n-butanol wherein the volume ratio of toluene:butanol is from 6:1 to 12:1 are absent, said composition including the following components:
______________________________________ ginkgo flavone glucosides 24 wt % proanthocyanidines 9 wt % ginkgolides 3.6 wt % bilobalide 3.1 wt % sulphuric ash 0.1 wt %. ______________________________________

### Claim 2 (depends on 1)

A composition according to claim 1 which is free of alkyl phenols.