# US 5,700,465 A · Bovine serum and bovine IgG as preventives and therapeutives for bovine mastitis

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- Number: US 5,700,465 A
- Document ID: US5700465A
- Status: Granted
- Kind: A
- Application number: 08/177,833
- Filed: 1994-01-05
- Granted: 1997-12-23
- Earliest claimed: 1994-01-05
- Assignees: American Cyanamid Company
- Inventors: Weng Tao; Martin John Corbett; Walter C. Pickett
- Web page: https://patentgrep.com/patent/US5700465A

## CPC

- C07K 16/00: Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Immunoglobulin G-2 (IgG2), e g. bovine IgG2, and its reaction with neutrophils can be used to enhance the neutrophil's functional status in host animal defense against bacterial infections.

## Claims

### Claim 1

A method of treating infection caused by Staphylococcus aureus in bovine animal host cells comprising administering an appropriate dosage of monomeric bovine IgG2 immunoglobulin obtained from non-immunized animals to a bovine animal host whereby the IgG2 immunoglobulin reacts with IgG2-Fc receptors and stimulates neutrophil function in the host animal cell.

### Claim 2

A method of preventing infection caused by Staphylococcus aureus in bovine animal host cells comprising administering an appropriate dosage of monomeric bovine IgG2 immunoglobulin obtained from non-immunized animals to a bovine animal host whereby the IgG2 immunoglobulin reacts with IgG2-Fc receptors and stimulates neutrophil function in the host animal cell.

### Claim 3 (depends on 1, 2)

The method of claim 1 or 2 wherein the appropriate dosage is between 10-100 mg.

### Claim 4 (depends on 1, 2)

The method of claim 1 or 2 wherein the dosage is administered by a route selected from the group consisting of intravenous injection, intramuscular injection, mammary gland infusion, and slow release formulation.

### Claim 5 (depends on 1, 2)

The method of claim 1 or 2 wherein the infection is bovine mastitis.

### Claim 6 (depends on 5)

The method of claim 5 wherein the bovine mastitis is contagious.

### Claim 7 (depends on 5)

The method of claim 5 wherein the bovine mastitis is environmental.