# US 5,700,454 A · Cosmetic composition containing an N-mercaptoalkylalkanediamide or one of its cosmetically acceptable salts as reducing agent

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- Number: US 5,700,454 A
- Document ID: US5700454A
- Status: Granted
- Kind: A
- Application number: 08/337,119
- Filed: 1994-11-10
- Granted: 1997-12-23
- Earliest claimed: 1993-11-12
- Assignees: L'oreal
- Inventors: Gerard Malle
- Web page: https://patentgrep.com/patent/US5700454A

## CPC

- A61K 8/46: containing sulfur (A61K8/44 takes precedence)
- A61Q 5/04: Preparations for permanent waving or straightening the hair
- C07C 323/12: the carbon skeleton being acyclic and saturated
- C07C 323/41: Y being a hydrogen or an acyclic carbon atom
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

A cosmetic composition for the first step of an operation for the permanent deformation of hair, the composition containing an N-mercaptoalkylalkanediamide or one of its cosmetically acceptable salts as a reducing agent, including new N-mercaptoalkylalkanediamide disulphides and new N-mercaptoalkylalkanediamides, and its use in a process for the permanent deformation of hair.

## Claims

### Claim 1

A cosmetic composition for the first step of an operation for permanent deformation of hair wherein disulphide bonds of keratin are reduced, the composition comprising at least one compound having the following formula (I): ##STR19## in which: A denotes the divalent radical --(CH.sub.2).sub.n --, n being an integer from 2 to 5, or the divalent radical --(CH.sub.2).sub.2 --O--(CH.sub.2).sub.2 --,
B denotes a radical, said radical being:
(a) the divalent radical --(CH.sub.2).sub.m --, m being an integer from 1 to 7,
(b) the divalent radical ##STR20## in which one of the groups R.sub.1, R.sub.2 and R.sub.3 denotes a radical, said radical being a linear or branched alkyl radical containing from 1 to 4 carbon atoms, methoxymethyl, phenyl, benzyl, cyclohexyl or cyclopentyl, and the other two groups are a hydrogen atom, p, q and r being 0 or an integer from 1 to 4 and wherein 1.ltoreq.p+q+r.ltoreq.4, and further wherein the p, q, or r corresponding to that radical R.sub.1, R.sub.2 or R.sub.3 which is said radical and is not a hydrogen atom is an integer from 1 to 4,
(c) the divalent radical ##STR21## in which R.sub.4 and R.sub.5 either, being identical or different, denote a linear or branched alkyl radical containing from 1 to 4 carbon atoms, or, together with the adjacent carbon atoms, form a cyclohexane or cyclohexene ring,
(d) the divalent radical ##STR22## in which one of R.sub.6 and R.sub.7 denotes an --NH.sub.2 radical and the other denotes a hydrogen atom; t being equal to 0 or 1, or
(e) the divalent radical ##STR23## in which R.sub.8 and R.sub.9 either, being identical or different, denote a hydrogen atom or a linear or branched alkyl radical containing from 1 to 4 carbon atoms or, together with the adjacent carbon atoms, form a benzene ring,
R and R', which are identical or different, denote:
either a hydrogen atom or a radical, said radical being a linear or branched alkyl radical containing from 1 to 4 carbon atoms or a linear or branched hydroxyalkyl radical containing from 1 to 5 carbon atoms,
or R denotes a hydrogen atom and R' denotes an aminoalkyl radical --(CH.sub.2).sub.v --NR.sub.10 R.sub.11 in which v is an integer from 1 to 3 and R.sub.10 and R.sub.11, which are identical or different, denote a hydrogen atom or a linear or branched alkyl radical containing from 1 to 3 carbon atoms, R.sub.10 and R.sub.11 being incapable of simultaneously denoting a hydrogen atom,
or an organic salt or an inorganic salt of said at least one compound of formula (I), and a cosmetically acceptable carrier, wherein said composition additionally contains at least one disulphide, the composition being self-neutralizing.

### Claim 2 (depends on 1)

The composition according to claim 1, wherein said said at least one disulphide corresponds to the following formula (II): ##STR24## in which A, B, R and R' are defined as in claim 1.

### Claim 3 (depends on 1)

The composition according to claim 1, wherein said at least one disulphide is present in a molar proportion, relative to the compound of formula (I), of from 0.5 to 2.5.

### Claim 4 (depends on 3)

The composition according to claim 3, wherein said at least one disulphide is present in a molar proportion, relative to the compound of formula (I), of from 1 to 2.