# US 5,700,451 A · Sunscreen composition

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- Number: US 5,700,451 A
- Document ID: US5700451A
- Status: Granted
- Kind: A
- Application number: 08/448,942
- Filed: 1995-05-24
- Granted: 1997-12-23
- Earliest claimed: 1995-05-24
- Assignees: The Procter & Gamble Company
- Inventors: Jiang Yue; Lisa Renee Dew; Donald Lynn Bissett
- Web page: https://patentgrep.com/patent/US5700451A

## CPC

- A61K 8/042: {Gels}
- A61K 8/29: Titanium; Compounds thereof
- A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
- B82Y 5/00: Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
- B82Y 30/00: Nanotechnology for materials or surface science, e.g. nanocomposites
- C09C 1/0084: {containing titanium dioxide}
- C09C 1/3607: {Titanium dioxide}
- A61K 2800/413: Nanosized, i.e. having sizes below 100 nm
- C01P 2002/02: Amorphous compounds
- C01P 2002/04: Compounds with a limited amount of crystallinty, e.g. as indicated by a crystallinity index
- C01P 2002/60: Compounds characterised by their crystallite size
- C01P 2002/84: by UV- or VIS- data
- C01P 2004/04: obtained by TEM, STEM, STM or AFM
- C01P 2004/62: Submicrometer sized, i.e. from 0.1-1 micrometer
- C01P 2004/64: Nanometer sized, i.e. from 1-100 nanometer
- C01P 2006/22: Rheological behaviour as dispersion, e.g. viscosity, sedimentation stability
- C01P 2006/60: Optical properties, e.g. expressed in CIELAB-values
- C01P 2006/80: Compositional purity
- C01P 2006/82: water content
- Y10T 428/2982: Particulate matter [e.g., sphere, flake, etc.]
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- B82Y: SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- C09C: TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES (treatment of materials specially adapted to enhance their filling properties in mortars, concrete or artificial stone C04B14/00, C04B18/00, C04B20/00); PREPARATION OF CARBON BLACK {; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS}
- C01P: INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

A TiO.sub.2 hydrogel and method of preparation therefor is disclosed: TiO.sub.2 particles ranging in size from at least about 50 nm to about 150 nm wherein the particle is about 20% to about 90% anatase are disclosed. Topical sunscreen compositions, which comprise 1% to about 15% anatase/amorphous TiO.sub.2 are also disclosed. This composition provides UVA and UVB protection without concomitant dulling or discoloring the skin. The composition also has enhanced stability, is invisible, is easy to apply in an even manner and resists discoloration (or "color-changing") or decomposition on the shelf or on the skin.

## Claims

### Claim 1

A topical composition comprising:
a) as an active from about 1% to about 15% anatase crystal in amorphous TiO.sub.2 chosen from the group consisting of;
1) a hydrogel comprising about 20% to about 60% solids comprising about 20% to about 90% anatase crystal in amorphous TiO.sub.2 having average crystalline domain dimensions of about 3 nm to about 10 nm; and
2) a TiO.sub.2 particle comprising about 20% to about 90% anatase form wherein the particles are from about 50 nm to about 150 nm in size; and
b) a cosmetically acceptable topical carrier.

### Claim 2 (depends on 1)

A composition according to claim 1 wherein the composition is a sunscreen.

### Claim 3 (depends on 1)

A topical composition according to claim 1 wherein the anatase crystal in amorphous TiO.sub.2 is incorporated as a hydrogel.

### Claim 4 (depends on 1)

A topical composition according to claim 1 wherein the hydrogel has average crystalline dimensions of about 5 nm.

### Claim 5 (depends on 1)

A topical composition according to claim 1 comprising as an active from about 1% to about 15% anatase crystal in amorphous TiO.sub.2 particles from about 20% to about 90% anatase form, ranging in size from at least about 50 nm to about 150 nm in size.

### Claim 6 (depends on 5)

A topical composition according to claim 5 wherein the particles are from about 20% to about 80% anatase form.

### Claim 7 (depends on 5)

A topical composition according to claim 5 wherein the particles range in size from at least about 60 nm to about 70 nm in size.

### Claim 8 (depends on 7)

A topical composition according to claim 7 wherein the particles are from about 20% to about 80% anatase form, ranging in size from about 60 nm to about 70 nm in size.

### Claim 9 (depends on 1)

A topical composition according to claim 1 wherein the composition is a non-discoloring sunscreen.

### Claim 10 (depends on 1)

A topical composition according to claim 1 wherein the composition is invisible upon application.

### Claim 11 (depends on 1)

A topical composition according to claim 1 wherein the composition is a UVA and UVB shielding sunscreen.

### Claim 12 (depends on 1)

A topical composition, useful as a sunscreen according to claim 1 wherein the composition is an emulsion chosen from the group consisting of a water-in-oil emulsion and an oil-in-water emulsion.