# US 5,700,427 A · Apparatus for carrying out electrochemiluminescence test measurements

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- Number: US 5,700,427 A
- Document ID: US5700427A
- Status: Granted
- Kind: A
- Application number: 08/462,605
- Filed: 1995-06-05
- Granted: 1997-12-23
- Earliest claimed: 1993-05-14
- Assignees: IGEN International, Inc.
- Inventors: Ali Ghaed; Jonathan K. Leland; Glenn D. Zoski; Jack E. Goodman; John T. Grosser
- Web page: https://patentgrep.com/patent/US5700427A

## CPC

- G01N 21/69: specially adapted for fluids {, e.g. molten metal}
- G01N 21/76: Chemiluminescence; Bioluminescence
- G01N 35/025: {having a carousel or turntable for reaction cells or cuvettes}
- G01N 2035/00356: {Holding samples at elevated temperature (incubation)}
- G01N 2035/0486: {Gearing, cams}
- Y10S 435/808: Optical sensing apparatus
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

An apparatus is taught for carrying out electrochemiluminescent measurements which includes a working electrode and a temperature sensor. The electrochemiluminescent measurements made by the apparatus are adjusted based upon the measured temperature.

## Claims

### Claim 1

An apparatus for use in carrying out electrochemiluminescence test measurements, comprising:
a cell for containing an electrochemiluminescent sample fluid;
a working electrode having an electrode surface within the cell;
a supply of electrical energy coupled with the working electrode for supplying electrical energy to the electrochemilunminescent sample fluid within the cell;
temperature sensor means for sensing a temperature of the electrochemiluminescent sample fluid and for producing a temperature signal representing said temperature;
output signal producing means for producing an output signal representing a detected value based on light produced through electrochemiluminescence of the sample fluid within the cell; and
a programmable control system, coupled with the supply of electrical energy, the temperature sensor means, and the output signal producing means, for controlling the application of electrical energy to the electrochemiluminescent sample fluid and the production of the output signal in accordance with an assay control program stored in the programmable control system, said programmable control system further controlling the output signal producing means to adjust the output signal based upon the temperature signal to produce a temperature effect adjusted output signal.

### Claim 2 (depends on 1)

The apparatus of claim 1, wherein the programmable control system is operative to store the assay control program as a plurality of programs and to run said plurality of programs simultaneously.

### Claim 3 (depends on 1)

The apparatus of claim 1, further comprising a program input for receiving the assay control program in the programmable control system and a program memory, the programmable control system being operative to store the received assay control program in the program memory.

### Claim 4 (depends on 3)

The apparatus of claim 3, wherein the program input comprises a communications port.

### Claim 5 (depends on 1)

The apparatus of claim 1, wherein the cell comprises a flow cell having a fluid inlet to receive the electrochemiluminescent sample fluid and a fluid outlet to conduct the electrochemiluminescent sample fluid from the flow cell, the apparatus further comprising a fluid transport system coupled with the fluid inlet and the fluid outlet for conducting the sample fluid to the fluid inlet and conducting the sample fluid from the fluid outlet, the programmable control system being coupled with the fluid transport system to control operation thereof in accordance with the assay control program.

### Claim 6 (depends on 5)

The apparatus of claim 5, wherein the programmable control system is operative to store the assay control program as a plurality of programs and to run said plurality of programs simultaneously.