# US 5,699,800 A · Stereotactic examination arrangement for conducting magnetic resonance examinations > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 5,699,800 A - Document ID: US5699800A - Status: Granted - Kind: A - Application number: 08/564,643 - Filed: 1995-11-29 - Granted: 1997-12-23 - Earliest claimed: 1994-11-30 - Assignees: Siemens Aktiengesellschaft - Inventors: Sylvia Heywang-Koebrunner - Web page: https://patentgrep.com/patent/US5699800A ## CPC - G01R 33/28: Details of apparatus provided for in groups G01R33/44 - G01R33/64 - A61B 90/10: for stereotaxic surgery, e.g. frame-based stereotaxis - G01R 33/3678: {involving quadrature drive or detection, e.g. a circularly polarized RF magnetic field} - G01R 33/281: {Means for the use of in vitro contrast agents (G01R33/282 takes precedence; involving use of a contrast agent in MR imaging G01R33/5601; in vivo contrast agents A61K49/0002)} - G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A stereotactic auxiliary attachment for magnetic resonance examinations has an antenna arrangement for receiving magnetic resonance signals from an examination space, a holder for fixing an examination subject in the examination space and a marker arrangement in the detection region of the antenna arrangement having at least one chamber for containing a substance to provide a reference for localizing an object of interest in the examination subject. The at least one chamber is connected via lines to a refilling device. The refilling device is provided for filling the at least one chamber with a first substance or second substance, the two substances having different magnetic resonance behavior. The chamber is filled with one substance for production of a first MR tomogram, and this substance is then removed from the chamber and replaced with the second substance for producing a second MR tomogram. Since the substances have different magnetic resonance behavior, the marks in the first and second tomograms remain visible when a subtraction image is produced from those tomograms, so the localization information is not lost. ## Claims ### Claim 1 A stereotactic examination arrangement for a magnetic resonance imaging apparatus, said arrangement comprising: holder means for fixing an examination subject in an examination space; antenna means for receiving magnetic resonance signals from said examination subject in said examination space, said antenna means having a detection region encompassing said examination space; marker means disposed in said detection region, and having at least one chamber containing a fluid, for producing a mark visible in a magnetic resonance image of said examination subject generated from said magnetic resonance signals obtained by said antenna means; and refilling means, in uninterrupted fluid connection with said at least one chamber, for selectively filling said chamber with one of first and second fluids, said first and second fluids having respectively different magnetic resonance behavior. ### Claim 2 (depends on 1) A stereotactic examination arrangement as claimed in claim 1 wherein said marker means is connected to said holder means. ### Claim 3 (depends on 1) A stereotactic examination arrangement as claimed in claim 1 wherein said refilling means comprises: a reservoir for said first fluid; and a pump in fluid communication with said reservoir for filling said at least one chamber with said first fluid and emptying said first fluid from said at least one chamber. ### Claim 4 (depends on 3) A stereotactic examination arrangement as claimed in claim 3 wherein said refilling means further comprises: a further reservoir for said second fluid; and a further pump in fluid communication with said further reservoir for filling said at least one chamber with said second fluid and emptying said second fluid from said at least one chamber. ### Claim 5 (depends on 4) A stereotactic examination arrangement as claimed in claim 4 wherein said further reservoir and said further pump comprise a unitary structure. ### Claim 6 (depends on 5) A stereotactic examination arrangement as claimed in claim 5 wherein said further pump comprises a piston removably disposed in an interior of said further reservoir for varying a volume of said interior of said further reservoir. ### Claim 7 (depends on 3) A stereotactic examination arrangement as claimed in claim 3 wherein said pump and said reservoir comprise a unitary structure. ### Claim 8 (depends on 7) A stereotactic examination arrangement as claimed in claim 7 wherein said pump comprises a piston movably disposed in an interior of said reservoir for varying a volume of said interior of said reservoir. ### Claim 9 A stereotactic examination arrangement as claimed in claim I wherein said holder means comprises two compression plates and means for moving said compression plates toward and away from each other. ### Claim 10 (depends on 9) A stereotactic examination arrangement as claimed in claim 9 wherein said marker means comprises two chambers with one chamber disposed on each said compression plate, and said refilling means comprising fluid lines connected to each of said chambers. ### Claim 11 (depends on 1) A stereotactic examination arrangement as claimed in claim 1 wherein said holder means comprises means for holding an examination subject for conducting a biopsy of said examination subject. ### Claim 12 (depends on 11) A stereotactic examination arrangement as claimed in claim 11 wherein said holder means comprises a plurality of through-holes adapted for guided access of a biopsy needle to said examination space from an exterior of said holder means. ### Claim 13 (depends on 1) A stereotactic examination arrangement as claimed in claim 1 further comprising a housing containing said holder means and said antenna means, said housing having an opening therein providing access to said examination space. ### Claim 14 A stereotactic examination arrangement for a magnetic resonance imaging apparatus, said arrangement comprising: holder means for fixing an examination subject in an examination space; antenna means for receiving magnetic resonance signals from said examination subject in said examination space, said antenna means having a detection region encompassing said examination space associated therewith; marker means disposed in said detection region, and having at least one chamber containing a fluid, for producing a mark visible in a magnetic resonance image of said examination subject generated from said magnetic resonance signals obtained by said antenna means; and refilling means, for successively filling and emptying said at least one chamber with a first fluid and a second fluid, said refilling means comprising a first reservoir containing said first fluid, a second reservoir containing said second fluid, valve means in fluid communication with said first reservoir, said second reservoir and said at least one chamber for selectively placing one of said first reservoir or said second reservoir in fluid communication with said at least one chamber, first pumping means in fluid communication with said first reservoir for filling said at least one chamber with said first fluid and emptying said first fluid from said at least one chamber when said first reservoir is in fluid communication with said at least one chamber via said valve means, and second pumping means in fluid communication with said second reservoir for filling said at least one chamber with said second fluid and emptying said second fluid from said at least one chamber when said second reservoir is in fluid communication with said at least one chamber via said valve means. ### Claim 15 (depends on 14) A stereotactic examination arrangement as claimed in claim 14 wherein said marker means is connected to said holder means. ### Claim 16 (depends on 14) A stereotactic examination arrangement as claimed in claim 14 wherein said first reservoir and said first pump means comprise a first unitary structure and wherein said second reservoir and said second pump means comprise a second unitary structure. ### Claim 17 (depends on 16) A stereotactic examination arrangement as claimed in claim 16 wherein said first pump means comprises a first piston movably disposed in an interior of said first reservoir for varying a volume in the interior of said first reservoir and wherein said second pump means comprises a piston movably disposed in an interior of said second reservoir for varying a volume in the interior of said second reservoir. ### Claim 18 (depends on 14) A stereotactic examination arrangement as claimed in claim 14 wherein said holder means comprises two compression plates and means for moving said compression plates toward and away from each other. ### Claim 19 (depends on 18) A stereotactic examination arrangement as claimed in claim 18 wherein said marker means comprises two chambers with one chamber disposed on each said compression plate, and said refilling means comprising fluid lines connected to each of said chambers. ### Claim 20 (depends on 14) A stereotactic examination arrangement as claimed in claim 14 wherein said holder means comprises means for holding an examination subject for conducting a biopsy of said examination subject. ### Claim 21 (depends on 20) A stereotactic examination arrangement as claimed in claim 20 wherein said holder means comprises a plurality of through-holes adapted for guided access of a biopsy needle to said examination space from an exterior of said holder means. ### Claim 22 (depends on 14) A stereotactic examination arrangement as claimed in claim 14 further comprising a housing containing said holder means and said antenna means, said housing having an opening therein providing access to said examination space.