Diagnostic methods for monitoring functional charcteristics of an organ intended for transplantation
AssigneeBreonics, Inc.
InventorLauren Brasile
Life of this patent
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Abstract
The present invention is directed to methods and a device useful for measuring functional characteristics of an organ being perfused at near normal metabolism using an ex vivo warm preservation process/system. The functional characteristics include parameters reflecting organ metabolism measured from perfusate which has circulated through the organ, from organ product produced and collected from the organ, or from both the circulated perfusate and the collected organ product during the warm preservation process/system. The measured parameters may then be compared to reference intervals as a method of prospectively assessing functional capabilities of the organ posttransplantation.
Claims23
A method to prospectively determine potential function of an organ posttransplantation by measuring functional characteristics related to organ metabolism while the organ is being perfused in an ex vivo warm preservation process/system at near normal rate of metabolism, said method comprising measuring parameters of a fluid selected from the group consisting of organ product, circulated perfusate, and a combination thereof, during ex vivo warm preservation;
- and relating values of the measured parameters to reference interval values, wherein values of measured parameters outside the reference intervals may be indicia of organ damage or injury which may affect function of the organ posttransplantation.
A method for monitoring functional characteristics of an organ being preserved in an ex vivo warm preservation process/system at near normal rate of metabolism, said method comprising measuring parameters during ex vivo warm preservation of a fluid selected from the group consisting of organ product, and a circulated perfusate.
A method to prospectively determine potential function of an organ posttransplantation by measuring functional characteristics related to organ metabolism while the organ is being perfused in an ex vivo warm preservation process/system at near normal rate of metabolism, said method comprising measuring at least one parameter of a fluid selected from the group consisting of an organ product, circulated perfusate, and a combination thereof, during ex vivo warm preservation;
- and relating a value of said at least one measured parameter to a reference interval value, wherein a value of said at least one measured parameter outside the reference interval may be indicia of organ damage or injury which may affect function of the organ posttransplantation.
Dependencies are inferred from the claim text.