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AssigneesBoard of Regents, The University of Texas System, The Texas A&M University System
InventorsRobert E. Garfield, Alexandru T. Balaban, William A. Seitz, Douglas J. Klein, Melanie Lesko
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Nitric oxide has proved to mediate many important physiological processes. The nitric oxide donors of the present invention have a NONOate anion linked to an ortho-substituted aryl, a heteroaromatic substituent, asteroid, or a catecholamine. Preferred ortho substituents are alkoxy, halo, and alkyl. The cation of the salt is an alkali metal, an alkaline-earth metal, an ammonium or substituted ammonium group. Nitric oxide donors provided herein are more stable than that of nitrogen-bonded NONOates described previously. The by product left after release of NO, and the nitric oxide donors themselves, are very probably less carcinogenic than the corresponding nitrogen-bonded NONOates.
A method of inhibiting uterine contractions in a subject comprising administering a therapeutically effective amount to the subject of of a nitric oxide donor having the structure ##STR5## where R is 2-methoxyphenyl and M is an alkali metal, an alkaline-earth metal, an ammonium or substituted ammonium cation.
A method of supplying nitric oxide to a subject comprising administering to the subject a pharmacologically effective amount of a compound having the structure ##STR6## where R is 2-methoxyphenyl;
Dependencies are inferred from the claim text.