Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group
AssigneeRhone-Poulenc Rorer S.A.
InventorMalcolm Norman Palfreyman
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Abstract
This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.
Claims17
A compound of formula I ##STR36## wherein R.sup.1 is optionally substituted lower alkyl;
- R.sup.2 is optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally halo substituted or oxidized cyclothioalkyl, optionally halo substituted or oxidized cyclothioalkenyl, cycloalkyl substituted alkyl, or cycloalkenyl substituted alkyl;
- and
- Z.sup.1 and Z.sup.2 are independently oxygen or sulfur;
- or
- a salt thereof,
- provided that when Z.sup.2 is oxygen, R.sup.1 is optionally substituted lower alkyl and R.sup.2 is optionally substituted cycloalkyl, then the optionally substituted cycloalkyl is multicyclic or at least one of R.sup.1 and R.sup.2 is substituted.
A compound, or a salt thereof which is 3-cyclopentyloxy-4-methoxybenzoic acid, or a salt thereof.
(New) A compound of formula I ##STR37## wherein R.sup.1 is lower alkyl;
- R.sup.2 is cycloalkyl;
- Z.sup.1 is oxygen or sulfur;
- and
- Z.sup.2 is oxygen;
- or
- a salt thereof.
A compound which is:
- 3-cyclohexyloxy-4-methoxybenzoic acid;
- 3-cyclopentyloxy-4-methoxybenzoic acid;
- or
- 3-cyclopentyloxy-4-(methylthio)benzoic acid, or a salt thereof.
A compound of formula ##STR38## wherein R.sup.1 is optionally substituted lower alkyl;
- R.sup.2 is optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally halo substituted or oxidized cyclothioalkyl, optionally halo substituted or oxidized cyclothioalkenyl, cycloalkyl substituted alkyl, or cycloalkenyl substituted alkyl;
- and
- Z.sup.1 and Z.sup.2 are independently oxygen or sulfur.
Dependencies are inferred from the claim text.