Product and process for targeting an immune response
AssigneeNational Jewish Center for Immunology and Respiratory Medicine
InventorDavid A. Nemazee
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Abstract
The present invention relates to a product and process for regulating an immune system using an immunoglobulin fusion protein capable of targeting a specific peptide precursor to a specific antigen presenting cell. Disclosed is a peptide precursor associated with an immunoglobulin molecule capable of binding to an antigen on the surface of an antigen presenting cell. Also disclosed is a nucleic acid molecule having a sequence encoding an immunoglobulin fusion protein comprising a peptide precursor and an immunoglobulin molecule. The invention is additionally directed to therapeutic reagents which can act as toleragens or immunogens useful in the regulation of an immune response.
Claims27
An immunoglobulin fusion protein which delivers a peptide comprising an antigenic peptide to a targeted antigen presenting cell, comprising an immunoglobulin molecule linked within the variable region of said immunoglobulin molecule to a peptide comprising an antigenic peptide, wherein said variable region binds to a target antigen on the surface of a specific antigen presenting cell thereby targeting said immunoglobulin fusion protein to said specific antigen presenting cell.
An immunoglobulin fusion protein which delivers a peptide comprising an antigenic peptide to a targeted antigen presenting cell, comprising an immunoglobulin molecule linked within the variable region of said immunoglobulin molecule with a peptide comprising an antigenic peptide, wherein said variable region binds to a target antigen on said targeted antigen presenting cell that distinguishes between types of antigen presenting cells.
Dependencies are inferred from the claim text.