Tissue specific viral vectors
AssigneeCalydon, Inc.
InventorsDaniel Robert Henderson, Eric Rodolph Schuur
Life of this patent
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Abstract
Host cell specific adenovirus vehicles are provided for transfecting target host cells. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication will be restricted to the target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity for treating neoplasia.
Claims12
An adenovirus vector comprising an adenovirus early gene essential for propagation under the transcriptional control of a prostate cell specific response element for transcription of prostate specific antigen comprising an enhancer and promoter specific for a prostate cell.
An adenovirus vector comprising at least one of the genes E1A, E1B, or E4 under the transcriptional control of a prostate cell specific response element.
An adenovirus vector comprising a transgene under the transcriptional control of a prostate cell specific response element and lacking at least one of E1A, E1B, or E4 as a functional gene.
An adenovirus vector which is replication competent only in mammalian cells expressing prostate specific antigen.
Dependencies are inferred from the claim text.