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US 5,698,432 AGranted
Vaccines and methods for their production
AssigneeRetroscreen Ltd.
InventorJohn Sidney Oxford
Life of this patent
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Abstract
The present invention relates to the production of vaccines having improved safety, particularly to a process therefor which allows even an AIDS vaccine to be manufactured, comprising in order, the steps of: a) treating the virus with a general inactivating agent; b) deaggregating the virus with a suitable solvent or detergent; c) treating the virus with an RNA and/or DNA inactivating agent; and d) stabilizing the virus with a suitable cross-linking agent.
Claims13
A process for producing inactivated whole virus, the process comprising, in order, the steps of:
- a) treating a virus with a general inactivating agent;
- b) treating the virus with a suitable deaggregating agent;
- c) treating the virus with a suitable nucleic acid inactivating agent;
- and
- d) stabilizing the virus with a suitable cross-linking agent.
2 more elements
Dependencies are inferred from the claim text.