Induction of cytotoxic T-lymphocyte responses
AssigneeIDEC Pharmaceuticals Corporation
InventorsSyamal Raychaudhuri, William H. Rastetter, Amelia Black
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Abstract
Methods and compositions useful for inducing a cytotoxic T lymphocyte response (CTL) in a human or domesticated or agriculturally important animal. The method includes the steps of providing the antigen to which the CTL response is desired and providing an antigen formulation which comprises, consists, or consists essentially of two or more of a stabilizing detergent, a micelle-forming agent, and an oil. This antigen formulation is preferably lacking in an immunostimulating peptide component, or has sufficiently low levels of such a component that the desired CTL response is not diminished. This formulation is provided as a stable oil-in-water emulsion.
Claims9
A composition comprising a papillomavirus antigen mixed with a microfluidized antigen formulation comprising:
- (a) a stabilizing detergent,
- (b) a micelie-forming agent, and
- (c) a biodegradable and biocompatible oil,
- said antigen formulation being formulated as a stable oil-in-water emulsion, said antigen formulation being substantially free of immunostimulating peptides and wherein said composition upon administration to an animal selected from the group consisting of humans, domesticated animals and agricultural animals is capable of inducing a specific cytotoxic T-lymphocyte response against the papillomavirus antigen contained in the composition.
Dependencies are inferred from the claim text.