Embolizing compositions
AssigneeMicro Therapeutics, Inc.
InventorsScott Evans, Michael L. Jones, Richard Greff
Life of this patent
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Abstract
Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery. In one embodiment, the compositions of this invention comprise a biocompatible polymer, a biocompatible solvent and a biocompatible water insoluble contrast agent characterized by having an average particle size of less than about 10 .mu.m. In another embodiment, the biocompatible polymer in these compositions is replaced with a biocompatible prepolymer.
Claims46
A composition comprising:
- (a) from about 2.5 to about 8.0 weight percent of a biocompatible polymer;
- (b) from about 10 to about 40 weight percent of a water insoluble, biocompatible contrast agent having an average particle size of about 10 .mu.m or less;
- and
- (c) from about 52 to about 87.5 weight percent of a biocompatible solvent
- wherein the weight percent of the polymer, contrast agent and biocompatible solvent is based on the total weight of the complete composition.
A method for embolizing a blood vessel by delivering via a catheter into said blood vessel a composition comprising:
- (a) from about 2.5 to about 8.0 weight percent of a biocompatible polymer;
- (b) from about 10 to about 40 weight percent of a water insoluble, biocompatible contrast agent having an average particle size of about 10 .mu.m or less;
- and
- (c) from about 52 to about 87.5 weight percent of a biocompatible solvent
- wherein the weight percent of the polymer, contrast agent and biocompatible solvent is based on the total weight of the complete composition
- under conditions wherein a precipitate is formed which embolizes the blood vessel.
A composition comprising:
- (a) a biocompatible prepolymer;
- (b) a water insoluble biocompatible contrast agent having an average particle size of about 10 .mu.m or less;
- and
- (c) a biocompatible solvent.
A method for embolizing a vascular site by delivering via a catheter into said blood vessel a composition comprising:
- (a) a biocompatible prepolymer;
- (b) a biocompatible water insoluble contrast agent having an average particle size of about 10 .mu.m or less;
- and
- (c) optionally a biocompatible solvent
- wherein said delivery is conducted under conditions wherein said prepolymer polymerizes in situ at said vascular site thereby embolizing the blood vessel and further wherein said non-particulate agent is encapsulated within said polymer.
A kit of parts comprising:
- (a) a polymer composition comprising a biocompatible polymer, a biocompatible solvent and a water insoluble, biocompatible contrast agent having an average particle size of about than 10 .mu.m or less;
- and
- (b) a catheter.
A kit of parts comprising:
- (a) a prepolymer composition comprising a biocompatible prepolymer, a water insoluble biocompatible contrast agent having an average particle size of about 10 .mu.m or less, and, optionally, a biocompatible solvent;
- and
- (b) a catheter.
Dependencies are inferred from the claim text.