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US 5,693,809 AGranted
Substituted 4-aza-5.alpha.-androstan-ones as 5.alpha.-reductase inhibitors
AssigneeMerck & Co., Inc.
InventorsPhilippe L. Durette, William Hagmann, Gary H. Rasmusson, Richard L. Tolman, Ihor E. Kopka, Soumya P. Sahoo, Craig K. Esser, Nathan G. Steinberg, Donald W. Graham, Bruce E. Witzel
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Abstract
Described are new 16-substituted and 7,16-disubstituted 4-aza-5.alpha.-androstan-3-ones and related compounds as 5.alpha.-reductase inhibitors.
Claims1
A compound selected from:
- 20(R)-methoxy-4,16.beta.-dimethyl-5.alpha.-4-aza-pregnan-3-one,
- 20(R)-allyloxy-4,16.beta.-dimethyl-5.alpha.-4-aza-pregnan-3-one,
- 20(R)-n-propyloxy-4,16.beta.-dimethyl-5.alpha.-4-aza-pregnan-3-one, and
- 20(R)-(3-methyl-2-butenyloxy)-4,16.beta.-dimethyl-5.alpha.-4-aza-pregnan-3- one.
1 more element
Dependencies are inferred from the claim text.