Alkylated amine polymers
AssigneeGelTex Pharmaceuticals, Inc.
InventorsW. Harry Mandeville, III, Stephen Randall Holmes-Farley
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Abstract
The invention relates to alkylated amine polymers and a method for removing bile salts from a patient that includes administering to the patient a therapeutically effective amount of product produced by a process comprising alkylating one or more crosslinked amine polymers, salts or copolymers thereof with at least one alkylating agent. The reaction product is characterized in that: (i) at least some of the nitrogen atoms are unreacted with alkylating agent; and (ii) less than 10 mol % of the nitrogen atoms in the polymer react with the alkylating agent to form quaternary ammonium units.
Claims38
An alkylated crosslinked polymer comprising the reaction product of:
- a) one or more crosslinked polymers, salts or copolymers thereof characterized by a repeat unit selected from the group consisting of:
- ##STR3## where n is a positive integer and each R, independently, is H or a C.sub.1 -C.sub.8 alkyl group;
- and
- b) at least one aliphatic alkylating agent, said reaction product characterized in that:
- (i) at least some of the nitrogen atoms in said repeat units are unreacted with said alkylating agent;
- and
- (ii) less than 10 mol % of the nitrogen atoms in said repeat units that react with said alkylating agent form quaternary ammonium units.
An alkylated crosslinked polymer comprising the reaction product of:
- a) one or more crosslinked polymers, salts or copolymers thereof characterized by a repeat unit having the formula ##STR4## where n is a positive integer and each R, independently, is H or a C.sub.1 -C.sub.8 alkyl group;
- and
- b) at least one aliphatic alkylating agent, said reaction product characterized in that:
- (i) at least some of the nitrogen atoms in said repeat units are unreacted with said alkylating agent;
- and
- (ii) less than 10 mol % of the nitrogen atoms in said repeat units that react with said alkylating agent form quaternary ammonium units.
An alkylated crosslinked polymer comprising the reaction product of:
- a) one or more crosslinked polymers, salts or copolymers thereof characterized by a repeat unit selected from the group consisting of:
- ##STR6## where n is a positive integer and each R, independently, is H or a C.sub.1 -C.sub.8 alkyl group;
- and
- b) at least one aliphatic alkylating agent, said reaction product characterized in that:
- (i) at least some of the nitrogen atoms in said repeat units are unreacted with said alkylating agent;
- (ii) less than 10 mol % of the nitrogen atoms in said repeat units that react with said alkylating agent form quaternary ammonium units;
- and
- (iii) said polymer is crosslinked by means of a multifunctional crosslinking agent, said agent being present in an amount from 1-10% by weight based upon the combined weight of monomer and crosslinking agent.
An alkylated crosslinked polymer comprising the reaction product of:
- a) one or more crosslinked polymers, salts or copolymers thereof characterized by a repeat unit selected from the group consisting of:
- ##STR7## where n is a positive integer and each R, independently, is H or a C.sub.1 -C.sub.8 alkyl group;
- and
- b) at least one hydrophobic aliphatic alkylating agent, said reaction product characterized in that:
- (i) at least some of the nitrogen atoms in said repeat units are unreacted with said alkylating agent;
- and
- (ii) less than 10 mol % of the nitrogen atoms in said repeat units that react with said alkylating agent form quaternary ammonium units.
An alkylated crosslinked polymer comprising the reaction product of:
- a) one or more crosslinked polymers, salts or copolymers thereof characterized by a repeat unit selected from the group consisting of:
- ##STR8## where n is a positive integer and each R, independently, is H or a C.sub.1 -C.sub.8 alkyl group;
- and
- b) at least one alkylating agent, having the formula RX wherein R is a C.sub.1 -C.sub.20 alkylammonium group and X is an electrophilic leaving group, said reaction product characterized in that:
- (i) at least some of the nitrogen atoms in said repeat units are unreacted with said alkylating agent;
- and
- (ii) less than 10 mol % of the nitrogen atoms in said repeat units that react with said alkylating agent form quaternary ammonium units.
Dependencies are inferred from the claim text.