Heterocyclic-substituted alkyl amide acat inhibitors

A compound of the formula

• wherein n is 0, 1, or 2;
• wherein R.sub.1 is selected from
• (a) phenyl which is substituted with from one to three substituents selected from:
• alkyl having from one to four carbon atoms and which is straight or branched,
• alkoxy having from one to three carbon atoms and which is straight or branched,
• alkylthio having from one to three carbon atoms and which is straight or branched,
• hydroxy,
• phenyl,
• fluorine,
• chlorine,
• bromine,
• nitro,
• cyano,
• trifluoromethyl,
• --COOH,
• --COOalkyl wherein alkyl has from one to four carbon atoms and which is straight or branched,
• --(CH.sub.2).sub.m NR.sub.5 R.sub.6 wherein m is 0 or 1, and each of R.sub.5 and R.sub.6 is hydrogen or a straight or branched alkyl group having one to four carbon atoms;
• (b) 1- or 2-naphthyl which is unsubstituted or substituted with one to three substituents selected from:
• alkyl having from one to four carbon atoms and which is straight or branched,
• alkoxy having from one to three carbon atoms and which is straight or branched,
• hydroxy,
• fluorine,
• chlorine,
• bromine,
• nitro,
• cyano,
• trifluoromethyl,
• --COOH,
• --COOalkyl wherein alkyl has from one to four carbon atoms and is straight or branched,
• --(CH.sub.2).sub.m NR.sub.5 R.sub.6 wherein m, R.sub.5, and R.sub.6 have the meanings defined above;
• (c) a straight or branched hydrocarbon group having from one to 18 carbon atoms which is saturated or is unsaturated containing one double bond or two nonadjacent double bonds;
• or
• (d) a cycloalkyl group having from three to eight carbon atoms;
• R.sub.2 is hydrogen;
• R.sub.3 is a heteroaryl selected from a 5- or 6-membered monocyclic or fused bicyclic heterocyclic group containing at least one to four heteroatoms in at least one ring, said heteroatoms being nitrogen, oxygen, or sulfur and combinations thereof, said heterocyclic group being unsubstituted or substituted with an alkyl group having from one to four carbon atoms and the N-oxides thereof;
• wherein x is tetrazole;
• wherein R.sub.4 is a straight or branched hydrocarbon chain having from 12 to 20 carbon atoms and is saturated or is unsaturated and has one double bond or has two nonadjacent double bonds or is alkyl substituted with trifluoromethyl;
• and R.sub.4 is in the two position of the tetrazole ring and the side chain, ##STR14## is attached to the carbon atom of the tetrazole ring or a pharmaceutically acceptable salt or individual enantiomeric isomer thereof.