Fibrin D-domain multimer prostheses and methods for their production
AssigneesMcMaster University, ZymoGenetics, Inc.
InventorsFraser D. Rubens, Paul D. Bishop
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Abstract
Methods for coating a prosthetic surface with anti-thrombogenic, or anti-coagulant, proteins are disclosed. The methods involve contacting a surface of a prosthetic material with a composition containing multimers of fibrin degradation products. These multimers, preferably D-dimers, have cross-linked D-domains. The methods of the invention are useful for providing an anti-thrombogenic coating on prosthetic implants which are exposed to a patient's blood after implantation, for example vascular grafts and artificial heart valves.
Claims21
A method of treating a mammalian patient comprising the step of:
- implanting into the patient a surface coated prosthetic member prepared by contacting a prosthetic surface of said prosthetic member with a composition comprising multimers of fibrin degradation products in a suitable carrier, the multimers having cross-linked D-domains, to produce an anti-thrombogenic coating comprising said multimers on said prosthetic surface.
A method of treating a mammalian patient comprising the step of:
- implanting into the patient a surface coated prosthetic member prepared by contacting a surface of said prosthetic member with a composition comprising multimeric fibrin degradation products in a suitable carrier, said multimeric fibrin degradation products having cross-linked D-domains and said composition being substantially free of intact fibrin and fibrin degradation products other than said multimeric fibrin degradation products, to produce an anti-thrombogenic coating consisting essentially of said multimeric fibrin degradation products on said surface.
Dependencies are inferred from the claim text.