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US 5,693,034 AGranted
Lubricous polymer network
AssigneeSciMed Life Systems, Inc.
InventorsPaul J. Buscemi, Paul C. Slaikeu
Life of this patent
Estimating the term…
Abstract
A polymer network useful as a lubricous coating, the polymer network comprising a reaction product of a vinyl prepolymer and an uncrosslinked hydrogel retained within the reaction product such that the network exhibits a greater lubricity when wet.
Claims7
An angioplasty catheter including a composition coating the distal end of said catheter, the composition comprising:
- the reaction product of vinyl monomers selected from the group consisting of mono-, di- and tri-acrylates, styrene, and divinyl benzene said monomers being polymerizable to form a crosslinked polymer that adheres to the surface of the device and resists degradation from rubbing and hydration;
- a polymerization initiator;
- and an uncrosslinked linear, water-soluble, hydrophilic hydrogel selected from the group consisting of polyethylene oxide, polyacrylic acid, polyacrylamide, poly (sodium-4-styrenesulfonate), poly(3-hydroxybutyric acid), polyvinylpyrrolidone and 2-hydroxyethyl methacryate, said hydrogel being intertwined with the polymer so as to prevent the hydrogel from leaching out of the coating composition, the hydrogel being lubricous when wet and substantially unnoticeable on the surface when dry, and said monomers being polymerized in the presence of the hydrogel;
- and
- a solvent.
2 more elements
An angioplasty catheter including a drug delivery system coating the distal end of said catheter, said drug delivery system comprising:
- a reaction product of vinyl monomers selected from the group consisting of mono-, di- and tri-acylates, styrene and divinyl benzene, said monomers being polymerizable to form a crosslinked polymer that is adherent to a substrate on a medical device and resistant to degradation from rubbing and hydration;
- with an uncrosslinked linear, hydrophilic, water-soluble hydrogel selected from the group consisting of polyethyene oxide, polyacrylic acid, polyacrylamide, poly (sodium-4-styrenesulfonate), poly(3-hydroxybutyric acid), polypyrrolidone and 2-hydroxyethyl methyacrylate which is lubricous where wet and substantially-unnoticeable on the substrate when dry and retained within the reaction product, said monomers being polymerized in the presence of the hydrogel;
- and
- a drug miscible in water, and leachable from the coating.
1 more element
A catheter for insertion into a human body, the catheter comprising:
- (a) a shaft having a proximal and a distal and a lumen extending from proximal end to the distal end, wherein the distal end will be inserted into the human body, and
- (b) a polymer network disposed on a surface of the shit, the polymer network comprising a polymer formed by reacting of a vinyl monomer selected from the group consisting of mono-, di, and tri-acylates, styrene and divinyl benzene, with an uncrosslinked linear, hydrophilic, water-soluble hydrogel selected from the group consisting of polyethylene oxide, polyacrylic acid, polyacrylamide, poly(sodium-4-styrenesulfonate), poly(3-hydroxybutyric acid), polyvinylpyrrolidone and 2-hydroxyethyl methacrylate which is lubricous when wet and substantially-unnoticeable on the substrate when dry and retained within the reaction product, said monomers being polymerized in the presence of the hydrogel.
A medical device for insertion into a human body, the device comprising:
- (a) an elongate member having a proximal end and a distal end, wherein the distal end will be inserted into the human body, and
- (b) a polymer network disposed on a surface of the elongate member, the polymer network comprising a polymer formed by reacting a vinyl monomer selected from the group consisting of mono-, di- and tri-acrylates, styrene and divinyl benzene, with an uncrosslinked linear, hydrophilic, water-soluble hydrogel selected from the group consisting of polyethylene oxide, polyacrylic acid, polyacrylamide, poly(sodium-4-styrenesulfonate), poly(3-hydroxybutyric acid), polyvinylpyrrolidone and 2-hydroxyethyl methacrylate which is lubricous when wet and substantially-unnoticeable on the substrate when dry and retained within the reaction product, said monomers being polymerized in the presence of the hydrogel.
Dependencies are inferred from the claim text.