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US 5,691,455 AGranted
Gonadotropins with non-native disulfide bridges
AssigneeAkzo Nobel N.V.
InventorsPieter Diederik Jan Grootenhuis, Judith Christina Heikoop
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Abstract
The present invention relates to gonadotropins consisting of an .alpha. and .beta. subunit, said gonadotropins comprising non-native disulfide bridges, preferably non-native intersubunit disulfide bridges. The gonadotropins according to the invention have improved stability. The present invention furthermore provides for pharmaceutical compositions comprising said gonadotropins.
Claims20
A gonadotropin consisting of an .alpha. subunit and a .beta. subunit, wherein said gonadotropin comprises one or more non-native disulfide bridges.
Dependencies are inferred from the claim text.