APC antibodies
AssigneesThe Johns Hopkins University, University of Utah, Cancer Institute, Imperial Chemical Industries PLC
InventorsHans Albertsen, Rakesh Anand, Mary Carlson, Joanna Groden, Philip John Hedge, Geoff Joslyn, Kenneth Kinzler, Alexander Fred Markham, Yusuke Nakamura, Andrew Thliveris, Bert Vogelstein, Raymond L. White
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Abstract
A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
Claims8
A preparation of antibodies which specifically binds to a human APC (adenomatous polyposis coli) protein having an amino acid sequence as shown in SEQ ID NO:1, 2, or 7, and does not specifically bind to other human proteins.
A preparation of antibodies which specifically binds to a human APC protein which is the product of a mutant allele found in a tumor, wherein the antibodies do not specifically bind to other human proteins, and wherein the human APC protein is a mutant form of the amino acid sequence shown in SEQ ID NOS:2 and 7, and the mutant allele is a mutant form of the nucleotide sequence shown in SEQ ID NO:1.
Dependencies are inferred from the claim text.