Polysaccharide-bound nitric oxide-nucleophile adducts
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsDaniel J. Smith, Debashish Chakravarthy, Larry K. Keefer
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Abstract
A polymeric composition capable of releasing nitric oxide comprises a polysaccharide including a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group bound to the polymer; pharmaceutical compositions including the polymeric composition; and methods for treating biological disorders in which dosage with nitric oxide is beneficial. The compositions can be used as and/or incorporated into implants, injectables, condoms, prosthesis coatings, patches, and the like for use in a wide variety of medical applications.
Claims4
A polymeric composition capable of releasing nitric oxide, said composition comprising a polysaccharide including a nitric oxide-releasing N.sub.2 O.sub.2 ! functional group selected from the group consisting of X.brket open-st.N(O)NO! and N(O)NO.brket close-st.X, wherein X is an amine-group-containing moiety bonded to said .brket open-st.N(O)NO! or N(O)NO.brket close-st. and wherein the N.sub.2 O.sub.2 ! group is bonded in said polysaccharide through said moiety X.
A polymeric composition capable of releasing nitric oxide, said composition comprising a coprecipitation product of a polysaccharide and a compound comprising a nitric oxide-releasing N.sub.2 O.sub.2 ! functional group selected from the group consisting of X.brket open-st.N(O)NO! and N(O)NO.brket close-st.X, wherein X is an amine-group containing a moiety bonded to said .brket open-st.N(O)NO! or N(O)NO.brket close-st..
Dependencies are inferred from the claim text.