Polyoxypropylene/polyoxyethylene copolmers with improved biological activity
AssigneeCytRx Corporation
InventorsR. Martin Emanuele, Robert L. Hunter, Paula H. Culbreth
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Abstract
The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but are substantially free from the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior an polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable.
Claims21
A method for treating sickle cell anemia comprising administering to a human with sickle cell anemia a composition comprising a polyoxyethylene/polyoxypropylene block copolymer with the following general formula:
- HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H
- wherein "a" is an integer such that the molecular weight represented by the polyoxypropylene portion of the copolymer is between approximately 900 and 15000 daltons and "b" is an integer such that the molecular weight represented by the polyoxyethylene portion of the copolymer constitutes between approximately 5% and 90% of the copolymer and the polydispersity value is less than approximately 1.07.
A method for improving blood flow comprising administering to a human or animal a composition comprising a polyoxyethylene/polyoxypropylene block copolymer with the following general formula:
- HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H
- wherein "a" is an integer such that the molecular weight represented by the polyoxypropylene portion of the copolymer is between approximately 900 and 15000 daltons and "b" is an integer such that the molecular weight represented by the polyoxyethylene portion of the copolymer constitutes between approximately 5% and 90% of the copolymer and the polydispersity value is less than approximately 1.07.
A method for treating ischemia comprising administering to a human or animal with ischemia a composition comprising a polyoxyethylene/polyoxypropylene block copolymer with the following general formula:
- HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H
- wherein "a" is an integer such that the molecular weight represented by the polyoxypropylene portion of the copolymer is between approximately 900 and 15000 daltons and "b" is an integer such that the molecular weight represented by the polyoxyethylene portion of the copolymer constitutes between approximately 5% and 90% of the copolymer and the polydispersity value is less than approximately 1.07.
Dependencies are inferred from the claim text.