5-(2-imidazolinylamino)benzimidazole compounds useful as alpha-2-adrenoceptor agonists
AssigneeThe Procter & Gamble Company
InventorsThomas Lee Cupps, Sophie Eva Bogdan
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Abstract
The subject invention involves compounds having the following structure: ##STR1## wherein: (a) R is unsubstituted C.sub.1 -C.sub.3 alkanyl or alkenyl; (b) R' is selected from hydrogen; unsubstituted C.sub.1 -C.sub.3 alkanyl or alkenyl; unsubstituted C.sub.1 -C.sub.3 alkylthio or alkoxy; hydroxy; thiol; cyano; and halo; and (c) R" is selected from hydrogen, methyl, ethyl and i-propyl. The subject invention also involves pharmaceutical compositions containing such novel compounds, compositions thereof and the use of such compounds for preventing or treating respiratory, ocular and/or gastrointestinal disorders.
Claims2
Pharmaceutical composition comprising:
- (a) a safe and effective amount of a compound having the following structure:
- ##STR11## wherein:
- (1) R is unsubstituted alkanyl or alkenyl having from 1 to about 3 carbon atoms;
- (2) R' is selected from the group consisting of hydrogen;
- unsubstituted alkanyl or alkenyl having from 1 to about 3 carbon atoms;
- unsubstituted alkylthio or alkoxy having from 1 to about 3 carbon atoms;
- hydroxy;
- thiol;
- cyano;
- and halo;
- (3) R" is selected from the group consisting of hydrogen, methyl, ethyl and i-propyl;
- and
- (b) a pharmaceutically-acceptable carrier;
- and
- (c) an antihistamine chosen from the group comprising Loratadine, Cetirizine, Acrivastine;
- Astemizole;
- Terfenadine;
- Terfenadine Carboxylate;
- and Diphenhydramine.
Dependencies are inferred from the claim text.