Back to results
US 5,691,368 AGranted
Substituted oxazolidine calpain and/or cathepsin B inhibitors
AssigneeHoechst Marion Roussel, Inc.
InventorsNorton P. Peet, Shujaath Mehdi, Matthew D. Linnik, Michael R. Angelastro, Hwa-Ok Kim
Life of this patent
Estimating the term…
Abstract
This invention relates to oxazolidine inhibitors of calpain and/or cathepsin B and to compositions containing them. As inhibitors of calpain and/or cathepsin B, the compounds are useful in the treatment of patients afflicted with acute or chronic neurodegenerative disorders.
Claims16
A compound of the formula:
- ##STR77## wherein R and Q are each independently hydrogen, OH, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, NO.sub.2, NH.sub.2 or halogen;
- R.sub.1 and R.sub.2 are each independently C.sub.1 -C.sub.4 alkyl;
- R.sub.3 is hydrogen, C.sub.1 -C.sub.8 alkanoyl, ##STR78## R.sub.4 and R.sub.5 are each independently hydrogen, C.sub.1 -C.sub.4 alkyl or benzyl;
- R.sub.6 is t-butyloxycarbonyl or carbobenzyloxy;
- R.sub.7 is hydrogen or methyl;
- R.sub.8 is C.sub.1 -C.sub.4 alkyl;
- m is the integer zero or one;
- n is the integer one;
- p is the integer zero to three;
- and
- q is the integer zero to three;
- with the proviso that one of R.sub.4 or R.sub.5 is hydrogen when the other of R.sub.4 or R.sub.5 is not hydrogen, methyl or ethyl;
- with the further proviso that one of m or n is one when the other of m or n is zero;
- or a pharmaceutically acceptable salt thereof.
11 more elements
Dependencies are inferred from the claim text.