Disubstituted heterocyclic thrombin inhibitors

A compound having the structure ##STR99## including all stereoisomers, wherein n is 0, 1 or 2;

• Z is NR.sup.7 or O, where R.sup.7 is H, lower alkyl, aryl or arylalkyl;
• G is an amido moiety which includes a cyclic member which is free of ##STR100## a group in the ring;
• R is hydrogen, hydroxyalkyl, hydroxyalkyl(alkyl), aminoalkyl, lower alkyl, cycloalkyl, arylalkyl, alkenyl, alkynyl, amidoalkyl, arylalkoxyalkyl or an amino acid side chain, either protected or unprotected;
• R.sup.1 is lower alkyl exclusive of methyl, cycloalkyl, aryl, or arylalkyl;
• or R.sup.1 and R.sup.2 together with the carbons to which they are attached form a cycloalkyl, aryl or heteroaryl ring;
• R.sup.2 and R.sup.3 are independently hydrogen, lower alkyl, cycloalkyl, aryl, arylalkyl, hydroxy, alkoxy, oxo, thioketal, thioalkyl, thioaryl, amino or alkylamino;
• or R.sup.2 and R.sup.3 together with the carbons to which they are attached form a cycloalkyl, aryl or heteroaryl ring;
• R.sup.4 is H, lower alkyl, arylalkyl, aryl, ##STR101## or --CO.sub.2 R.sup.5, where R.sup.5 is lower alkyl, aryl, arylalkyl, cycloheteroalkyl, heteroaryl, quinolinyl or tetrahydroquinolinyl;
• including pharmaceutically acceptable salts thereof.