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US 5,691,354 AGranted
N-1-4-(4-fluorophenoxy)butyl!-4-pi peridinyl!-N-methyl-amino!-2-benzothiazolols as class III antiarrhythmic agents
AssigneeJanssen Pharmaceutica NV
InventorsJozef Jan Pieter Heykants, Marcel Jan Maria Borgers, Doris Wilhelm
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Abstract
2-1-4-(4-fluorophenoxy)butyl!-4-piperidinyl!methylamino!-benzothiazolole s ##STR1## wherein R.sup.1 or R.sup.2 is hydroxy, the other variable always being hydrogen, and the pharmaceutically acceptable acid addition salts thereof. Novel compounds, pharmaceutical compositions, as well as their use as a class III antiarrhythmicum is disclosed.
Claims4
A method of treating subjects suffering from arrhythmia which comprises administering to such subjects a therapeutically effective amount of a compound of the formula:
- ##STR4## wherein one of the variables R.sup.1 and R.sup.2 is hydroxy, while the other is hydrogen, and the pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.