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US 5,691,352 AGranted
Stable pharmaceutical composition of terfenadine and ibuprofen
AssigneeMerrell Pharmaceuticals Inc.
InventorsKeith D. Ertel, David F. Long
Life of this patent
Estimating the term…
Abstract
The present invention is directed to a chemically stable pharmaceutical composition containing ibuprofen in combination with terfenadine, wherein the oxidation of terfenadine to terfenadone is prevented by the presence in the composition of an .alpha.-hydroxy carboxylic acid.
Claims3
A chemically stable pharmaceutical composition comprising:
- (a) a therapeutically effective analgesic amount of ibuprofen or a pharmaceutically acceptable salt thereof;
- (b) a therapeutically effective antihistaminic amount of terfenadine or a pharmaceutically acceptable salt thereof;
- and,
- (c) a dicarboxylic acid.
1 more element
A chemically stable pharmaceutical composition comprising:
- (a) a therapeutically effective analgesic amount of ibuprofen or a pharmaceutically acceptable salt thereof;
- (b) a therapeutically effective antihistaminic amount of terfenadine or a pharmaceutically acceptable salt thereof;
- and,
- (c) tartaric acid.
1 more element
A chemically stable pharmaceutical composition comprising:
- (a) a therapeutically effective analgesic amount of ibuprofen or a pharmaceutically acceptable salt thereof;
- (b) a therapeutically effective antihistaminic amount of terfenadine or a pharmaceutically acceptable salt thereof;
- and,
- (c) tartronic acid.
1 more element
Dependencies are inferred from the claim text.