Bis-(Heteroarylmethoxyphenyl)cycloalkyl carboxylates as inhibitors of leukotriene biosynthesis

A compound having the structural formula I:

• ##STR38## or a pharmaceutically acceptable salt thereof wherein m is an integer of 1 to 9, inclusive;
• n is an integer of 1 to 4, inclusive;
• W is the same at each occurrence and is selected from the group consisting of
• (a) unsubstituted quinolyl;
• (b) quinolyl substituted with one, two, or three substituents selected from the group consisting of
• halogen,
• C.sub.1-6 alkyl, and
• C.sub.1-6 alkoxy;
• (c) unsubstituted benzothiazoyl;
• (d) benzothiazoyl substituted with one, two, or three substituents selected from the group consisting of
• halogen,
• C.sub.1-6 alkyl, and
• C.sub.1-6 alkoxy;
• (e) unsubstituted quinoxalyl;
• and
• (f) quinoxalyl substituted with one, two, or three substituents selected from the group consisting of
• halogen,
• C.sub.1-6 alkyl, and
• C.sub.1-6 alkoxy;
• Y is one to four substituents independently selected from
• halogen,
• C.sub.1-6 alkyl, and
• C.sub.1-6 alkoxy;
• X is absent or is selected from the group consisting of
• (a) C.sub.1-6 alkylene;
• (b) C.sub.1-6 alkenylene;
• and
• (c) C.sub.1-6 alkynylene;
• Z is selected from the group consisting of
• (a) COB;
• (b) C(R.sup.2).sub.2 --O--N.dbd.A--COB;
• and
• (c) C(R.sup.2).dbd.N--O--A--COB where
• A is C.sub.1-6 alkylene, and
• B is selected from the group consisting of
• (a) --OH,
• (b) --O.sup.- M.sup.+ where M is a pharmaceutically acceptable cation;
• (c) --OR.sup.6 where R.sup.6 is hydrogen or alkyl of one to six carbon atoms;
• (d) --NR.sup.6 R.sup.7 where R.sup.6 is as previously defined and R.sup.7 is selected from the group consisting of
• hydrogen,
• alkyl of one to six carbon atoms,
• hydroxy, and
• alkoxy or from one to six carbon atoms, or
• R.sup.6 and R.sup.7, together with the atom to which
• they are attached, form a ring of five to eight members containing one optional heteratom selected from N, and S;
• and
• (e) --O--D where D is a metabolically cleavable group.