Method for inhibiting vasoconstriction

A method of inhibiting vasoconstrictive activity in warm-blooded animals comprising administering to warm-blooded animals a vasoconstrictively inhibiting effective amount of at least one compound selected from the group consisting of all possible racemic isomers, enantiomers and diastereoisomers of a compound of the formula ##STR46## wherein one of A and B is nitrogen and the other is carbon, the dotted lines indicate that the pyridinyl ring is optionally unsaturated, R is butyl, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are individually selected from the group consisting of a) --(CH.sub.2).sub.m1 --S(O).sub.m2 --X--R.sub.14, m1 is an integer from 0 to 4, m2 is an integer from 0 to 2, when m1 is other than 0, X--R.sub.14 is --NH.sub.2 or mono or di-alkyl or alkenyl-amino of up to 6 carbon atoms or mono or di-phenyl amino, all optionally substituted with at least one member of the group consisting of halogen, --OH, alkyl and alkoxy of 1 to 4 carbon atoms, --CF.sub.3, free, salified or esterified carboxy, --CN and tetrazolyl and whatever the value of m1, R.sub.14 is selected from the group consisting of optionally substituted alkyl and alkenyl of up to 6 carbon atoms and optionally substituted aryl with at least one member of the group consisting of --OH, halogen, alkyl and alkoxy of 1 to 4 carbon atoms, --CF.sub.3, free, esterified, salified or amidified carboxy, --CN and tetrazolyl and X is selected from the group consisting of a single bond, ##STR47## m3 is an integer:

• from 0 to 2, R.sub.15 and R.sub.16 are individually hydrogen or R.sub.14 and ##STR48## is defined as e), b) hydrogen, halogen, --OH, --CN, --NO.sub.2, formyl, benzoyl, acyl of up to 12 carbon atoms and free, salified esterified or amidified carboxy, c) alkyl, alkenyl, alkynyl, alkoxy, acyloxy, alkylthio, alkylsulfinyl and alkylsulfonyl, all having up to 6 carbon atoms and optionally substituted, d) cycloalkyl, aryl, arylalkenyl, aryloxy, aralkoxy, arylthio, arylsulfinyl and arylsulfonyl, the alkyl and alkenyl portion having up to 6 carbon atoms and the aryl is a monocyclic of 5 to 6 ring members or a condensed ring of 8 to 14 ring members optionally containing at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen and optionally substituted, ##STR49## R.sub.17, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are individually selected from the group consisting of hydrogen, alkyl and alkenyl of up to 6 carbon atoms optionally substituted with a member of the group consisting of halogen, --OH and alkoxy of 1 to 6 carbon atoms, --(CH.sub.2).sub.m1 --S(O).sub.m2 --X--R.sub.14 and aryl and arylalkoxy of 1 to 6 alkyl carbon atoms and the aryl is monocyclic of 5 to 6 ring members or a condensed cycle of 8 to 14 ring members optionally containing at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen and optionally substituted with at least one member of the group consisting of halogen, --OH, --NO.sub.2, free, salified, esterified or amidified carboxy and alkyl, alkenyl, alkoxy and acyl of up to 6 carbon atoms of R.sub.6 and R.sub.7 or R.sub.8 and R.sub.9 taken with the nitrogen atom form a monocyclic of 5 to 6 ring members or a condensed cyclic of 8 to 14 ring members optionally containing at least one heteroatom selected from the group consisting of --O--, --S-- and nitrogen and optionally substituted with at least one member of the group consisting of halogen, --O, --NO.sub.2, free, salified, esterified or amidified carboxy and alkyl, alkenyl, alkynyl, alkoxy and acyl of up to 6 carbon atoms or R.sub.8 and R.sub.9 are individually acyl of a carboxylic acid of up to 6 carbon atoms, R.sub.5 is ##STR50## Y is Y.sub.1 B--Y.sub.2, Y.sub.1 is a monocyclic arylene of 5 to 6 ring members optionally substituted with at least one of the substituents of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 and B is a single bond between Y.sub.1 and Y.sub.2 or B is a divalent member of the group consisting of --CO--, --NH--CO-- and --O--(CH.sub.2).sub.n -- and when B is a single bond, Y.sub.2 is a member of the group consisting of hydrogen, halogen, --CN, free salified, esterified or amidified carboxy, tetrazolyl and (CH.sub.2).sub.m1 --S(O).sub.m2 --X--R.sub.14 as defined above or for any value of B other than a single bond, Y.sub.2 is selected from the values defined for Y.sub.1 and their non-toxic, pharmaceutically acceptable salts with bases and acids.