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US 5,691,340 AGranted
Benzopyran derivatives
AssigneeAdir et Compagnie
InventorsGenevieve Baziard-Mouysset, Sallouma Younes, Youssef Labssita, Marc Payard, Daniel-Henri Caignard, Pierre Renard, Marie-Claire Rettori
Life of this patent
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Abstract
A compound selected from those of formula (I): ##STR1## where RA, RB, RC, RD, A, n, X, Y and Ar are defined in the description, and a medicinal product comprising the same for treating a mammal afflicted with a disease associated with sigma receptors.
Claims6
A compound selected from those of formula (I):
- ##STR17## in which Ar represents phenyl, naphthyl, substituted phenyl or substituted naphthyl,
- n represents an integer of 1 to 4 inclusive,
- RB and RC together form a --(CH.sub.2).sub.q -- bridge with q having the value 1 or 2 and, in this case, A represents a --(CH.sub.2).sub.p -- bridge with p representing 0, or 1 and such that p+q=2, and in this case RA represents hydroxyl or alkoxy situated in the 5-position of the aromatic ring which carries it or RA represents hydrogen or halogen, in any position on the aromatic ring,
- or RB and RC together form a --CH.dbd. bridge, and the bond which bonds it to the aromatic ring is single, and in this case A represents CH.sub.2 and RA represents hydrogen, hydroxyl or alkoxy situated in the 5-position of the aromatic ring which carries it,
- or RB and RC together form a single bond and then A represents a group ##STR18## the carbonyl being bonded to the oxygen and the bond connecting A to the carbon carrying the side chain is double, and in this case RA represents hydrogen, hydroxyl or alkoxy,
- X and Y each represent hydrogen and RD, which only exists when all the bonds of the carbon which carries it are single, represents hydrogen,
- it being understood that, except when otherwise mentioned,
- the terms "alkyl" and "alkoxy" denote linear or branched saturated groups having 1 to 6 carbon atoms inclusive,
- the term "substituted" concerning the phenyl and naphthyl substituents means that the latter can be substituted by one to three groups chosen from hydroxyl, alkyl, alkyl substituted by one or a number of halogens, alkoxy and halogen,
- an optical isomer thereof in the pure form or in the form of a mixture, and an addition salt thereof with a pharmaceutically-acceptable acid or base.
7 more elements
Dependencies are inferred from the claim text.