1,2-dithiole-3 thiones for the treatment of reverse transcriptase-dependent viral infections
AssigneeSloan-Kettering Institute for Cancer Research
InventorsHans J. Prochaska, Bruce Polsky
Life of this patent
Estimating the term…
Abstract
This invention provides a method of inhibiting the replication of a reverse transcriptase-dependent virus in cells which comprises contacting infected cells with an effective amount of a 1,2-dithiole-3-thione. A composition for inhibiting reverse transcriptase-dependent viral replication of cells comprising an effective amount of a 1,2-dithiole-3-thione and a physiologically acceptable carrier is also provided.
Claims15
A method of inhibiting the replication of a reverse transcriptase-dependent virus which comprises contacting cells infected with a reverse transcriptase-dependent virus with an amount effective to inhibit replication of the reverse transcriptase-dependent virus in the cells, of a 1,2-dithiole-3-thione having the structure:
- ##STR3## wherein X is a C.sub.1 -C.sub.5 alkyl group or is --CH.sub.2 COOR, R being a C.sub.1 -C.sub.5 alkyl group, and wherein Y is a 5- or 6-membered heterocyclic aromatic ring, 1-3 ring atoms of which are nitrogen, oxygen, or sulphur, the remaining ring atoms being carbon.
Dependencies are inferred from the claim text.