Oxy-phenyl-(phenyl)glycinolamides with heterocyclic substituents
AssigneeBayer Aktiengesellschaft
InventorsUlrich Muller, Richard Connell, Siegfried Goldmann, Klaus-Helmut Mohrs, Siegfried Raddatz, Michael Matzke, Rudi Grutzmann, Martin Beuck, Stefan Wohlfeil, Hilmar Bischoff, Dirk Denzer
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Abstract
Oxy-phenyl-(phenyl)glycinolamides with heterocyclic substituents are prepared by reaction of the corresponding oxyphenylcarboxylic acids with heterocyclic substituents with phenylglycinol. The new substances are suitable as active compounds in medicaments, in particular in agents having an antiatherosclerotic action.
Claims5
Oxy-phenyl-(phenyl)glycinolamides with heterocyclic substituents, of formula (I) ##STR82## in which A represents naphthyl, or represents a group of the formula ##STR83## wherein R.sup.1 and R.sup.2 are identical or different and denote hydrogen, halogen, hydroxyl or straight-chain or branched alkoxy having up to 4 carbon atoms,
- D and E are identical or different and represent hydrogen, cycloalkyl having 3 to 8 carbon atoms, azido, hydroxyl, halogen, straight-chain or branched alkyl, alkoxy or alkenyl having in each case up to 6 carbon atoms, or a 5- to 6-membered unsaturated or saturated heterocyclic group having up to 3 hetero atoms from the series consisting of S, N and O, or represent a group of the formula --NR.sup.3 R.sup.4 or --NR.sup.5 SO.sub.2 R.sup.6, wherein
- R.sup.3, R.sup.4 and R.sup.5 are identical or different and denote hydrogen or straight-chain or branched alkyl having up to 4 carbon atoms or phenyl,
- R.sup.6 denotes straight-chain or branched alkyl having up to 4 carbon atoms, benzyl or phenyl, which is optionally substituted by straight-chain or branched alkyl having up to 4 carbon atoms,
- L represents a bond, or represents a group of the formula ##STR84## wherein R.sup.7 denotes hydrogen, hydroxyl, methoxy or hydrogen,
- R.sup.8 denotes hydrogen, hydroxyl, halogen, straight-chain or branched alkenyl or alkoxy having in each case up to 8 carbon atoms or cycloalkyl or cycloalkenyl having in each case 3 to 14 carbon atoms, or denotes straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by cycloalkyl having 3 to 8 carbon atoms, phenyl or tetrahydropyranyl, which in their turn can be substituted by halogen, or denotes a group of the formula --CH.sub.2 SIR.sup.9 R.sup.10 R.sup.11 or an indanyl group, wherein
- R.sup.9, R.sup.10 and R.sup.11 are identical or different and denote straight-chain or branched alkyl having up to 4 carbon atoms or
- R.sup.7 and R.sup.8 together with the carbon atom form a saturated carbocyclic ring having 5 to 7 carbon atoms, which is optionally substituted up to mice in an identical or different manner by straight-chain or branched alkyl having up to 4 carbon atoms, or
- R.sup.7 and R.sup.8 together form a group of the formula .dbd.O or a double bond group of the formula ##STR85## wherein a denotes the number 2, 3, 4, 5 or 6, and salts thereof.
Dependencies are inferred from the claim text.