N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides
AssigneeMerck & Co., Inc.
InventorsDavid A. Claremon, Roger M. Freidinger, Nigel Liverton, Harold G. Selnick, Garry R. Smith
Life of this patent
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Abstract
This invention is concerned with novel compounds represented by structural formula I ##STR1## which are useful in the treatment of arrhythmia.
Claims12
A compound of the structural formula I ##STR19## where R.sup.1 and R.sup.3 are independently C.sub.1-6 alkyl, either straight or branched chain;
- substituted C.sub.1-6 alkyl, either straight or branched chain wherein the substituents are selected from F, C.sub.3-8 cycloalkane, --OH, --CF.sub.3, and
- Z is
- 1) C.sub.1-6 alkyl, either straight or branched chain,
- 2) substituted C.sub.1-6 alkyl, either straight or branched chain, wherein the substituents are selected from F, OH, NO.sub.2,
- 3) C.sub.2-4 alkenylene, either straight or branched chain,
- 4) C.sub.3-6 cycloalkane,
- 5) C.sub.3-6 cycloalkylene, or
- 6) single bond;
- R.sup.2 is
- 1) phenyl, either unsubstituted or substituted with one or two substituents selected from
- a) --NO.sub.2, --OH,
- b) --Cl, Br, F, or I,
- c) --CF.sub.3,
- d) --C.sub.1-3 alkyl,
- e) --C.sub.1-3 alkoxy,
- f) --CN,
- g) -methylenedioxy,
- 2) C.sub.5-7 cycloalkyl, either unsubstituted or substituted with one or two substituents selected from
- a) --NO.sub.2,
- b) --F,
- c) --CF.sub.3,
- d) --C.sub.1-3 alkyl,
- e) --C.sub.1-3 alkoxy,
- f) --CN,
- g) --methylenedioxy,
- or pharmaceutically acceptable salts, hydrates and crystal forms thereof.
A method of preventing or treating arrhythmia which comprises the administration to a patient in need of such treatment of an antiarrhythmically effective amount of the compound of the structural formula ##STR34## wherein R.sup.1 and R.sup.3 are independently C.sub.1-6 alkyl, either straight or branched chain;
- substituted C.sub.1-6 alkyl, either straight or branched chain wherein the substituents are selected from F, C.sub.3-8 cycloalkane, --OH, --CF.sub.3, and
- Z is
- 1) C.sub.1-6 alkyl, either straight or branched chain,
- 2) substituted C.sub.1-6 alkyl, either straight or branched chain, wherein the substituents are selected from F, OH, NO2,
- 3) C.sub.2-4 alkenylene, either straight or branched chain,
- 4) --(CH.sub.2)m--W--(CH.sub.2).sub.n -- wherein m and n are independently 0, 1, 2, 3 or 4 and W is --O--, --S-- or --NH,
- 5) C.sub.3-6 cycloalkane,
- 6) C.sub.3-6 cycloalkylene, or
- 7) single bond;
- R.sup.2 is
- 1) phenyl, either unsubstituted or substituted with one or two substituents selected from
- a) --NO.sub.2, --OH,
- b) --Cl, Br, F, or I,
- c) --CF.sub.3,
- d) --C.sub.1-3 alkyI,
- e) --C.sub.1-3 alkoxy,
- f) --CN,
- g) -methylenedioxy,
- C.sub.5-7 cycloalkyl, either unsubstituted or substituted with one or two substituents selected from
- a) --NO.sub.2,
- b) --F,
- c) --CF.sub.3,
- d) --C.sub.1-3 alkyl,
- e) --C.sub.1-3 alkoxy,
- f) --CN,
- g) -methylenedioxy,
- or pharmaceutically acceptable salts, hydrates and crystal forms thereof.
Dependencies are inferred from the claim text.