Phosphoethanolamine conjugates of vitamin D compounds
AssigneeClarion Pharmaceuticals Inc.
InventorsAndrew C. Peterson, Parvin T. Yazdi
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Abstract
Certain phosphoethanolamine conjugates of vitamin D compounds are disclosed wherein the phosphoethanolamine moiety is bonded at the 3-position of the vitamin D moiety. The conjugates exhibit anti-tumor, anti-psoriatic and anti-inflammatory activities in addition to those activities associated with vitamin D. The invention embraces the novel compounds, pharmaceutical compositions thereof, and their methods of use.
Claims23
A conjugate of a vitamin D moiety with a phosphoethanolamine moiety of formula ##STR6## at the 3-position of the vitamin D moiety, wherein R.sup.1 is hydrogen or methyl, provided that at least one R.sup.1 is methyl, all isomeric forms of the conjugate, and pharmaceutically acceptable salts of the conjugate and all isomeric forms thereof.
Dependencies are inferred from the claim text.