Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis
AssigneePro-Neuron, Inc.
InventorsReid W. von Borstel, Michael K. Bamat, Bradley M. Hiltbrand
Life of this patent
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Abstract
Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.
Claims20
A method for treating tissue damage due to systemic inflammatory response syndrome comprising administering to an animal a therapeutically effective amount of uridine, cytidine, orotic acid, acylated uridine, acylated cytidine, or acylated orotic acid, or a pharmaceutically acceptable salt thereof.
A method for preventing tissue damage due to systemic inflammatory response syndrome comprising identifying an animal at risk for developing tissue damage due to systemic inflammatory response syndrome, and then administering to said animal a prophylactically effective mount of uridine, cytidine, orotic acid, acylated uridine, acylated cytidine, acylated orotic acid, or a pharmaceutically acceptable salt thereof.
A method for treating sepsis comprising administering to an animal a therapeutically effective amount of uridine, cytidine, orotic acid, acylated uridine, acylated cytidine, or acylated orotic acid.
A method for preventing sepsis comprising identifying an animal at risk for developing sepsis, and then administering to said animal aprophylactically effective amount of uridine, cytidine, orotic acid, acylated uridine, acylated cytidine, or acylated orotic acid.
A method for treating sepsis comprising administering to an animal a therapeutically effective amount of an inhibitor of uridine phosphorylase.
A method for preventing sepsis comprising identifying an animal at risk for developing sepsis, and then administering to said animal a prophylactically effective amount of an inhibitor of uridine phosphorylase.
A method for reducing toxicity of a therapeutic cytokine or inflammatory stimulus comprising administering to a animal a therapeutically effective mount of uridine, cytidine, orotic acid, acylated uridine, acylated cytidine, acylated orotic acid, or a pharmaceutically acceptable salt thereof, prior to, during, or after administration of said cytokine or said stimulus.
A method for reducing toxicity of a therapeutic cytokine or inflammatory stimulus comprising administering to an animal a therapeutically effective amount of an inhibitor of uridine phosphorylase prior to, during, or after administering said cytokine or said stimulus.
Dependencies are inferred from the claim text.