Cyclodextrin cellular delivery system for oligonucleotides
AssigneeHybridon, Inc.
InventorsSudhir Agrawal, Qiuyan Zhao, Ivan Habus
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Abstract
Disclosed is a composition including an oligonucleotide complexed with a cyclodextrin. The oligonucleotide may be noncovalently associated with the cyclodextrin. Alternatively, the oligonucleotide may be covalently complexed with adamantane which is noncovalently associated with the cyclodextrin. Also disclosed are methods of enhancing the cellular uptake and intracellular concentration of oligonucleotides, methods of increasing the solubility of an oligonucleotide in a cell, and methods of treating a cell for viral infection or to prevent viral infection.
Claims16
A composition comprising adamantane which is covalently linked to an oligonucleotide phosphorothioate or oligonucleotide phosphodiester and noncovalently complexed with a cyclodextrin.
A composition comprising an oligonucleotide phosphorothioate or oligonucleotide phosphodiester noncovalently complexed with a cyclodextrin.
Dependencies are inferred from the claim text.