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US 5,691,306 AGranted
Methods of detection and treatment of protein trafficking disorders and increasing secretory protein production
AssigneeNational Research Council of Canada
InventorsJohn J. M. Bergeron, David Y. Thomas, Ikuo Wada
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Abstract
The present invention provides compositions and methods for increasing secretory protein production. In another aspect, the present invention provides compositions for use in methods of treating and diagnosing protein trafficking disorders. These methods generally involve the alteration of calnexin activity to increase protein secretion or retention.
Claims8
A method of increasing secretory protein production in an ex vivo biological preparation, comprising:
- administering a calnexin suppressor agent to a biological preparation in an amount effective to increase secretory protein production.
Dependencies are inferred from the claim text.