Detergent compositions

A detergent composition for washing fabrics composed of proteinogenic fibers comprising a proteolytically active amount of a Bacillus lentus protease selected from the group consisting of F49 variant having S3T+V4I+A188P+V193M+V199I+L211D mutations, F46 variant having 3ST+V4I+S154E+A188P+V193M+V199I or combination thereof having a keratinase/caseinase activity ratio of less than about 0.80 and a nonionic surfactant selected from the group consisting of a fatty alkyl polyglycoside, a fatty alkyl polyalkoxylate, a fatty acid polyhydroxyamide, an ethoxylated fatty alkylamine, a propoxylated fatty alkylamine, an ethoxylated vicinal diol, a propoxylated vicinal diol, an ethoxylated fatty acid alkyl ester, a propoxylated fatty acid alkyl ester, an ethoxylated fatty acid amide, a propoxylated fatty acid amide, and mixtures thereof.

A detergent composition for washing fabrics composed of proteinogenic fibers comprising a proteolytically active amount of a Bacillus lentus protease selected from the group consisting of F49 variant having S3T+V4I+A188P+V193M+V199I+L211D, F46 variant having 3ST+V4I+S154E+A188P+V193M+V199I mutations and combinations thereof having a keratinase/caseinase activity ratio of less than about 0.80 and an anionic surfactant selected from the group consisting of a fatty alkyl sulfate, a fatty alkyl ether sulfate, a sulfofatty acid ester, a sulfofatty acid disalt, and combinations thereof.

A composition comprising first and second mutant proteases wherein in said first mutant protease at least one of the amino acid residues at positions 99 and 154 are different from those in Bacillus lentus DSM 5483 and wherein in said second mutant protease at least the amino acid residue at position 211 is different from that in Bacillus lentus DSM 5483.

A detergent composition comprising at least one surfactant and at least a first and second mutant protease wherein in said first mutant protease at least one of the amino acid residues at positions 99 and 154 are different from those in Bacillus lentus DSM 5483 and wherein in said second mutant protease at least the amino acid residue at position 211 is different from that in Bacillus lentus DSM 5483.

A composition comprising at least one surfactant and a proteolytically active amount of first and second mutant proteases wherein in said first mutant protease at least one of the amino acid residues at positions 99 and 154 are different from those in Bacillus lentus DSM 5483 and wherein in said second mutant protease at least the amino acid residue at position 211 is different from that in Bacillus lentus DSM 5483.

A composition comprising at least one surfactant and a proteolytically active amount of first and second mutant Bacillus lentus proteases wherein each of said protease has an amino acid subsitution selected from the group consisting of R99G, R99A, R99S, S154D, S154E, L221 D, L211 E, and a combination thereof.