Isolated DNA sequence for a novel macrophage receptor with a collagenous domain
OwnerKarl Tryggvason, Outi Elomaa +1inventors
InventorsKarl Tryggvason, Outi Elomaa, Maarit Kangas
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Abstract
The present invention is directed to processes for isolating and identifying the nucleotide sequence of a gene for a novel macrophage receptor with collagenous structure, termed "MARCO". The new macrophage receptor with a collagenous domain binds gram positive and negative bacteria and acetylated LDL. Moreover, the invention relates to the nucleotide sequence for MARCO identified by the process of the invention and the isolated and purified polypeptide chain encoded by such a sequence.
Claims3
An isolated murine DNA sequence which codes for a macrophage receptor with a collagenous domain comprising SEQ ID NO. 1.
An isolated DNA sequence wherein said sequence codes for the 518 polypeptide of SEQ ID NO. 2, and wherein the polypeptide has a molecular weight of about 52,738 daltons.
Dependencies are inferred from the claim text.