Saccharomyces cerevisiae expressing M.sub.2 protein of influenza A virus
AssigneeBristol-Myers Squibb Company
InventorsStephen E. Kurtz, Mark Krystal
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Abstract
A modified Saccharomyces cerevisiae cell, wherein the cell expresses the Influenza virus ion channel protein M.sub.2. Also disclosed is a process for detecting modulators of M.sub.2, which comprises (a) treating such modified Saccharomyces cerevisiae cells with a test substance, and (b) assessing growth in the presence of a test substance, wherein a change in growth signals that the test substance is an M.sub.2 modulator. M.sub.2 inhibitors are useful anti-viral agents.
Claims10
A Saccharomyces cerevisiae cell comprising multiple copies of a plasmid that expresses a nucleic acid sequence for a M.sub.2 protein or a functional mutant or derivative thereof, wherein the M.sub.2 protein or functional mutant or derivative thereof is expressed at a level such that growth of a culture of the cells is impaired.
Dependencies are inferred from the claim text.